THE EFFECT OF GADOLINIUM ORTHOVANADATE NANOPARTICLES BY NEONATAL INDUCED REPRODUCTIVE DISEASE IN MALE RATS.

For the purpose to develop of method for treatment of male hypofertility the efficiency of gadolinium orthovanadate nanoparticles (NP GdVO4) in rats with neonatal induced reproductive disease, has been investigated. The progeny of intact rats parents were exposed to emotional stress (Maternal separation stressn) and received an excessive amount of the blend of phytoestrogens (Ph) with mother's milk (1st group) from 3 to 22 day life. At the age of 10 months males received NP GdVO4 (0.

[Experience of application of meronem in the treatment of severe purulent sepsis in children].

Results of antibacterial therapy with application of meropenem (meronem by firm Astra Zeneca, Great Britain) in 29 childs with severe purulent-septic state, including 5 with toxic peritonitis, in 2--with sepsis, in 3 newborn childs--with esophageal atresia and in 19--with the blood disease (nonhodgkin's lymphoma, an acute lymphoblastic or myeloblastic leucosis, reccurrent of acute lymphoblastic leucosis, nephroblastoma).

[Mechanisms for the therapeutic effect of herpes polyvaccines in chronic ophthalmic herpes and genital herpes].

Commercial inactivated culture polyvaccine against herpes simplex viruses (types 1 and 2) developed at D. I. Ivanovsky Institute of Virology promoted cessation of viremia.

[Impact of focal allergic test with herpetic vaccine in diagnosis of ophthalmic herpes].

Clinical and immunological studies were carried out in 697 patients (913 eyes) for a more accurate diagnosis of herpetic involvement of the posterior segment of the eye by the focal allergic test (FAT) based on the delayed type hypersensitivity phenomenon. FAT consists in detection of the focal reaction in the eye, regularly developing after 2-3 intracutaneous injections of herpetic vaccine to types I and II herpes simplex virus in a dose of 0.2 ml every other day.

[Dynamics of cellular immunity indices in patients with ophthalmic herpes treated with a herpetic polyvaccine].

Specific vaccine therapy resulted in clinical improvement or stabilization of the pathological process in some patients with herpetic conjunctivitis. The vaccine exerted an immunopotentiating effect on the immune status of the subjects under study the direction of which depended upon the initial status of the parameters examined. In some cases the positive clinical effect of the vaccine therapy was accompanied by a decrease in lymphocyte sensitization to herpes simplex virus and normalization of the lymphocyte count.