[Fetal arrhythmias: pathogenetic mechanisms and clinical aspects].

The paper contains analysis of literature data on pathogenesis, clinical aspects and treatment of various kinds of fetal arrhythmia as well as data of authors own studies in the field.

[Design of chimeric proteins based on a pentameric superhelical fragment of COMP. II. Properties of a hybrid, containing an VNTR (MUC1) antigen of human tumors].

An oligomeric chimeric protein DB-2 was constructed, to design drugs with antitumor activity and to develop highly sensitive immunospecific tests for the diagnostics of a wide variety of malignant epithelial cells in humans. DB-2 contains an immunodominant site of tetanus toxin and a fragment of the locus of the human tumor-associated antigen MUC1 with a variable number of tandem repeats. A pentameric superhelical fragment of the human cartilage oligomeric matrix protein was used as an oligomerization matrix.

[Design of chimeric proteins based on pentameric superhelical fragments of COMP. I. Properties of a hybrid containing an immunodominant segment of the surface protein of Plasmodium falciparum].

The oligomeric recombinant protein DB-1 containing the immunodominant sites of the circumsporozoite protein of Plasmodium falciparum and tetanus toxin was constructed to optimize the schemes of presentation of B-cell epitopes during vaccination with chimeric proteins without the use of adjuvants. A fragment of the pentameric coiled-coil human cartilage oligomeric matrix protein was used as an oligomerization matrix. The expression of the protein in Escherichia coli cells was studied, a method for its purification was developed, and it was biochemically characterized.

[The diagnostic characteristics of late toxicosis in pregnant women with hypertension and chronic kidney diseases].

A study was made of diagnostic significance (sensitivity and specificity) of early (precritical) signs of late gestosis (LG). A total of 179 females (187 pregnancies) with essential hypertension (EH) and chronic renal diseases (CRD) were examined. EH women are at high risk of LG when they have proteinuria above 0.

[The dynamic importance of proteinuria and arterial pressure for detecting late toxicosis in pregnant women with chronic kidney diseases and hypertension].

Time course of 187 pregnancies was followed up in 103 females with chronic renal diseases (CRD), 76 females with essential hypertension (EH) and 14 posteclampsia females. Three variants of arterial pressure (AP) and 5 types of proteinuria changes were recognized in CRD and EH patients. The pattern of these changes was compared to that in posteclampsia patients, the eclampsia being an absolute criterium of late toxicosis.

[Monitoring the activity of systemic lupus erythematosus in pregnancy].

To evaluate the effect of pregnancy on systemic lupus erythematosus (SLE) activity, the authors studied 35 patients with definite SLE (ARA criteria, 1982). SLE activity was estimated every trimester of pregnancy and 3-14 months after the delivery. The disease activity was judged by scores (SLEDAI, version I and II) and by an increase in prednisolone dose more than 5 mg/day.