The V-Block Occlusion Stent and Sclerotherapy Device for Varicose Vein Treatment: A Retrospective Analysis.

Background: The procedure aims to show our results with a novel nontumescent, nonthermal technique to treat varicose veins. The V-block occlusion stent is a minimally invasive device for treating reflux of the great saphenous vein (GSV). It is an office-based procedure that does not require tumescence anesthesia.

Protein folding: where is the paradox?

In this contribution we shall try to argue that no folding scenario - be it hierachical, nonhierarchical, nucleation, etc. - needs to be invoked to solve Levinthal's paradox: It fails on its own grounds.

Liver metastases from colorectal cancer: regional intra-arterial treatment following failure of systemic chemotherapy.

This study was designed to determine response rate, survival and toxicity associated with combination chemotherapy delivered intra-arterially to liver in patients with hepatic metastases of colorectal origin refractory to standard systemic treatment. A total of 28 patients who failed prior systemic treatment with fluoropyrimidines received a median of 5 cycles of intra-arterial treatment consisting of 5-fluorouracil 700 mg/m(2)/d, leucovorin 120 mg/m(2)/d, and cisplatin 20 mg/m(2)/d for 5 consecutive days. Cycles were repeated at intervals of 5-6 weeks.

Sequentially folded SV-11 RNA: metastability is relevant to biological function.

By simulating a Markov process comprising kinetically controlled elementary chain-growth steps and upstream refolding events, we compute the sequential folding of SV-11 RNA; a species capable of acting as a template instructing its own replication when folded into a metastable conformation. The predicted structure is endowed with available primers for replication and is identical within the regions of homology to the experimentally probed active structure of MNV-11 RNA, a species from which SV-11 RNA has evolved. The uneven rate of chain growth during SV-11 RNA replication and the pause sites along the replica sequence are determined.

Evidence of a tertiary interaction functional in group I 3'-splicing.

It has been recently shown that the schedule of 3'-splicing events for yeast mitochondrial group I introns requires that conserved helix P10 materializes only after 5'-cleavage has taken place. A scenario compatible with experimental findings has been proposed [(1992) FEBS Lett. 297, 201-204; (1990) Proc.

Preservation of a kinetically originated folding of the cis antirepressor sequence for transport of HIV-1 viral RNA.

We compute a metastable secondary structure for the cis antirepressor sequence (CAR) in the viral RNA of human immunodeficiency virus 1 (HIV-1) whose lifetime is long enough to allow for further stabilization by interaction with the ribosomal machinery. The structure emerges as the viral genome RNA is being synthesized by RNA polymerase II and corresponds to the biologically active structure sustained between units 7364 and in env RNA. It is the most probable among the fast-formed structures which emerge during transcription.