[Nephroprotective properties of third-generation beta-adrenoblockers].

Experimental and clinical data on the nephroprotector properties of third-generation beta-adrenoblockers nebivolol and carvedilol are reviewed. These properties are related to the antihypertensive effect and ability of drugs to suppress oxidative stress in glomerules, proximal renal tubules, and surrounding interstitial tissue.

[Mitotic activity in serous adenocarcinoma of the uterine body].

A comparative study of uterine serous (36) and endometrial (32) adenocarcinoma was undertaken. The former pathology revealed a higher mitotic index (18.2%) than the latter (11.

[Serous adenocarcinoma of the uterus: criteria of morphological diagnosis and immunohistochemistry].

The analysis of the histopathologic features in 138 patients with uterine serous adenocarcinoma in comparison with 146 patients with uterine endometrioid papillary adenocarcinoma revealed morphological specificities of these carcinomas. Immunohistochemical study found that 66.7% uterine serous adenocarcinomas were negative both to estrogen and progesterone receptors and 86.

[Risk of chronic stomach diseases and cancer in occupational exposure to monocyclic aromatic carbohydrates (benzol and its homologs)].

A statistically significant rise in the frequency of chronic atrophic gastritis, a precursor of cancer, has been identified in subjects exposed to monocyclic aromatic carbohydrates.

[Morphological differences between follicular lymphomas and follicular hyperplasia of the lymph nodes].

A study was performed in 80 patients with follicular lymphomas and 61 patients with follicular hyperplasia of lymph nodes. The sensitivity, specificity, prognostic value, and the positive and negative likelihood ratio of various histological differentially diagnostic parameters were estimated. The signs that are of great informative value were as follows: the presence (or absence) of concentric layers of mantle cells, follicular polarization, the presence of histiocytes with phagocytosed nuclear debris in the follicles and atypical follicular cells outside the follicles.

[The 300-th anniversary of pathologic anatomy in Saint-Petersburg].

The paper is an overview that covers a long historical period that was marked by the first autopsies (under Peter the First), the development of large research schools, the teaching of students, the training of pathologists, the origin of experimental pathology, the appearance of outstanding discoverers (N.N. Anichkow, A.

[Mechanisms of cellular defense in cadidiasis].

The data obtained in this research on experimental lung candidiasis in mice suggest that a specific part of cellular resistance (thymus) evidently fails to play the leading role in initiating the infectious process. The major function of hindering candidiasis development belongs to neutrophilic leucocytes whose phagocytosis is eliminating the causal agents from the organism.

[Modelling of opportunistic infection caused by the conditionally pathogenic fungi of the genus Candida].

The analysis of a wide range of experimental models indicates that none of them could be regarded as an adequate model of human candidiasis. Hence, at present, the reproduction of separate components of candidiasis is necessary under various effects on the body.

[Morphofunctional characteristics of the immunocompetent system in hypotrophy and its correction by thymogen].

Administration of the synthetic thymic peptide-thymogen to the pigs with symptoms of hypotrophy exerted a positive effect on the course of this pathological condition this resulting from the stimulation of the central and peripheral parts of the immunogenesis. 230 days after the treatment the positive effect still persisted.

[The effect of a synthetic thymus peptide (thymogen) on the immune system in candidiasis under immunodepression].

Experimental candidiasis developing against the background of the secondary immunodeficiency is described. After thymogen injections the course of candidiasis proceeds less severely, this suggesting that thymogen activates the immunocompetent system, including thymus, favouring the disappearance of the fungal infection.

[Morphologic manifestations of candidiasis in newborns with immunodeficiency].

Morphological examinations of 58 autopsy cases of visceral candidiasis in newborns were performed. Direct correlation between the severity of thymus lesions and the degree of changes in organs produced by candidiasis was observed. The most severe candidiasis was found in cases of congenital immunodeficiency.

[Fungus invasion in the morphogenesis of gastro-duodenal ulcers].

The goal of the study was the clarification of the role of the fungus Candida in the course of the ulcer. The combination of morphological, cultural and immunological methods was used for the diagnosis of the fungus involvement. Inhibition of the reparative processes by the fungus Candida was shown in the experiment on the model of the chronic gastric ulcer.

[Mental hygiene of family and marital relationships].

On the basis of clinical, specialized, and sociological examination of 1771 individuals (627, 430, and 714 respectively) the authors have attempted to determine factors and tendencies which adversely affect the durability of marriage, familial and marital harmony, and mental development of children. It is concluded that from the mental hygiene standpoint and with regard to primary psychoprophylaxis of borderline diseases it is necessary to improve moral and sexual education of children and adolescents, to further develop the general education of young people about to be married, to perfect the organization of psychologic and hygienic aid to young families, to initiate scientific and methodological development of the system of lectures aimed at propagation of mental hygiene knowledge among the population.

[Species characteristics of experimental Candida lung lesions].

Intratracheal challenge of rabbits and intranasal challenge of white mice and guinea-pigs by C. albicans without the application of adhesive substances, produced candidiasis pneumonia running more severe course in mice than in rabbits. In guinea-pigs the disease was of medium severity.

[Morphogenesis of candidiasis granuloma].

Fungi C. albicans killed by various methods were injected intravenously to mice resulting in the granuloma formation in the liver and spleen. These granulomas were similar to those developing in newborns affected with candidiasis.

[Morphofunctional state of organs of immunogenesis and adrenal glands after administration of a thymus preparation (thymaline)].

Comparative characterization of morphofunctional changes in the thymus, secondary immunogenesis organs, and adrenal cortex after 10-day subcutaneous inoculations of CBA mice with a thymus preparation, thymaline, showed enhanced thymus functioning and not very marked signs of migrational activity of lymphocytes in lymph nodes under conditions of a prolonged effect of thymaline in normal animals to run in a reduced hormonal activity of adrenocorticocytes.

[Differential diagnostic possibilities based on algorithms from histological study in cervical and vaginal diseases].

An algorithm of histological description of pathological processes in the cervix uteri and vagina is proposed to improve the quality of differential histological diagnosis of diseases of these organs. The algorithm ensures a better analysis of the data obtained by organizing the thinking of a pathologist, contributes to fuller and more fruitful use of recommendations of both descriptive and morphometric nature, and may be used for research and training and self-training of morphologists.