[Mechanisms of cerebral damage in patients with HIV-infection].

Mechanisms of HIV transportation through blood-brain barrier, vascular plexus and interaction with cerebral cells having CD-4-receptors, CCR-5- and CXCR-4-coreceptors were studied. Cerebral damage developed through latent and acute periods also known as HIV-encephalopathy, HIV-associated neurocognitive dysfunction etc. Cerebral lesions are caused by a variety of chemical agents from pro-inflammatory cytokines to toxic HIV-proteins resulting in development of HIV-dementia through several years.

[Student body selection for a regional medical graduate education training center].

The results of analysis of the composition of experts from the Northwestern region of the Russian Federation, who improved their skills at the Medical Academy of Postgraduate Training, Saint Petersburg, i.e. a regional training center for continuous postgraduate education of medical personnel, are presented in the article.

[Evaluation of the capacities of neurophysiological intraoperative monitoring in reconstructive surgery on the vertebral column].

Aim: To evaluate the capacities of neurosurgical intraoperative monitoring of somatosensory evoked potentials (SSEP) in reconstructive operations on the vertebral column.

Materials And Methods: The Center of Spinal Surgery examined 30 patients treated in February to July 2001. According to the diagnosis, the distribution was as follows: degenerative diseases of the vertebral column (80%), its tumors (10%), injury (7%), and inflammatory diseases (3%).

[Intraoperative colonic sorption dialysis in colonic cancer complicated with colonic obstruction].

The data on treatment 84 patients with large bowel carcinoma aggravated by occlusion ileus are discussed. The study group included 49 patients who received intraoperative sorption dialysis of large bowel (ISDLB). Intraoperative lavage of large bowel (ILLB) was given to 35 patients who were in control.

[Course of wound healing under the influence of polyfepan in patients with diabetes mellitus].

The results of the treatment of 140 patients with diabetes mellitus complicated with purulent process are analysed. The vulnerosorption with polyphepan was used in 68 patients. Polyphepan is a natural polymer obtained from a technical lignin.

[Use of enterosorption in biliary tract cancers complicated with mechanical jaundice].

Enterosorption using polyphepan in experimental mechanical jaundice was followed by improvement of the course of the disease, lower mortality and improvement in endotoxemia indices. The therapeutic effect of enterosorption is due to enhanced transfer of metabolites and toxins through the intestinal wall and subsequent excretion via the gastrointestinal tract. Enterosorption performed in 60 patients with malignancies of the bile tracts and mechanical jaundice was followed by a more rapid improvement in general condition and reduction in the indices of endotoxemia, as compared with 60 controls.

[Enterosorption in ulcerative lesions of the gastrointestinal tract with concomitant intestinal dysbacteriosis].

Adjuvant use of enterosorbents in combined therapy of gastroduodenal ulcers (158 patients), nonspecific ulcerative colitis with intestinal dysbacteriosis was assessed. Enterosorption in combined therapy of gastrointestinal diseases with dysbacteriosis potentiated positive effect. The highest benefit of enterosorption occurs in intestinal affections (nonspecific ulcerative colitis, irritable bowel-syndrome, chronic enteritis, colitis).

[Experimental and clinical validation of using enterosorption in mechanical jaundice].

Experiments in 119 rats with the model of mechanical jaundice have shown the efficiency of enterosorption with polyphepan. The development of the pathological process was found to improve, lethality of the experimental animals to decrease. Favourable changes of the laboratory indices characteristic of endotoxemia were noted.

[Circulating and pulmonary pool of leukocytes in respiratory disorders].

Total count of activated leukocytes in venous and arterial blood, intensity of leukocyte infiltration of the lung were measured in experimental animals (dogs) and patients with acute pulmonary diseases. Relationships between circulating and marginal leukocyte pools in pulmonary diseases are complicated and heterogeneous. There is a certain phase cycle when the lungs either capture the activated cells or the activation takes place in pulmonary vessels followed by the cell release into the systemic blood stream.

[Enterosorption as a method for correction of biogenic amine levels in experimental bronchospasm].

The mechanism of enterosorption positive influence on the course of bronchospastic condition was studied on the model of allergic bronchospasm. The using of the sorbent (polyphepan) during the period of sensitization of rats prevented the beginning of bronchospasm or reduced its extent. The results of investigation proved that a decrease the of biogenic amines concentration in biological liquids and tissues depending on their transport and sorption in intestine is one of the main mechanisms of enterosorption.

[The comparative activity of natural and synthetic enterosorbents in experimental hyperlipidemia].

In-vitro experiments have shown that dietary fibre microcrystalline cellulose and lignin (polyphepan) possess high activity in binding sodium salt of cholic acid. This action is comparable with that of pectin and metamucile. Hypolipidemic effect of microcrystalline cellulose, polyphepan and synthetic enterosorbents carbonates was also seen in hyperlipidemic rats.

[The nature of the changes in the content of regulatory peptides in the pulmonary vascular bed].

The data obtained in white rats and dogs' isolated lungs showed the blood level of peptides to fluctuate within 30-50% of the total peptides concentration in blood. The process is cyclic, its rhythm not depending on the peptides level in venous blood.

[Use of enterosorption for reducing the biogenic amine content of blood and exudate in peritonitis].

The administration of an enterosorbent prevents increase of the level of biologically active substances in blood and exudate of rats in fecal peritonitis. The results of biochemical and radionuclide methods of examination allow 2 mechanisms of reduction of the histamine and serotonin level in blood and exudate to be distinguished--direct and mediated.

[Pulmonary complications in severe cranio-cerebral injury].

An analysis of 2049 autopsies and experimental investigations in 150 albino rats have shown that pulmonary complications developing during the first two weeks after cranio-cerebral traumas include pulmonary edema, aspiration syndrome, pneumonia. The pulmonary injuries are based on several pathogenetic mechanisms associated with the effect of hemodynamics, humoral factors, activation of leukocytes, aspiration and infection. Disturbed hemodynamics and vascular permeability in the lungs can be due to functional alterations in the zone of vascular-motor and respiratory centers.

[Optical image processing in the analysis of the structural elements of the x-ray picture of the adult respiratory distress syndrome].

The paper is devoted to the potentialities of aposterior image processing in adult patients with the respiratory distress-syndrome (RDS). Thirty one cases of optical processing of radiograms were analyzed. Pulmonary changes were absent in 10 persons of the control group.

[Protective action of thyroliberin and its synthetic analog (PR-546) in craniocerebral trauma].

The effect of TRH and its synthetic analogue (PR-546) devoid of hormonal activity was studied in acute experiments on rats on the model of neurogenic lung edema caused by skull injury. It was proved that the preliminary (for 30 min before the injury) i/p introduction of TRH (in doses 0.5-1 mg/kg) and PR-546 (in doses 4-8 mg/kg) prevented the development of acute edema and the changes of blood gas compositions as well as disorders in breathing after skull injury.

[Radiologic features of respiratory distress syndrome].

An analysis of roentgenograms of 50 patients with a respiratory distress-syndrome has shown that roentgenosemiotics of this complication discloses alterations of permeability of pulmonary and bronchial capillaries, drainage of liquid from the interstice and alveoli, hemodynamics in the microcirculation link of the lesser circulation circle. A classification of the respiratory distress-syndrome is proposed which includes 3 stages and a period of involution of the process.