[Clinical significance of "night acid burst" phenomenon in patients with duodenal ulcer].

The article discloses the results of the examination and treatment of duodenal ulcer patients with or without "nocturnal gastric acid breakthrough". This phenomenon was recorded in 19% patients. They have night heartburn, complicated duodenal ulcer in anamnesis, on the one hand, and more long duration of ulcer healing, decreasing efficiency of eradication Helicobacter pylori, on the other hand.

[Circadian rhythms of acid production and alkalization in the stomach of healthy subjects and duodenal ulcer patients].

We studied 24-h rhythms of acid production and alkalization in 30 patients with duodenal ulcer (DU) and 30 healthy subjects using upper endoscopic examination and computer intragastric pH-metry. Gastric acid production was higher in DU patients and was more intensive in the daytime than at night. Healthy subjects had low and monotonous acid production.

[Characteristics of the psychological status of patients with peptic ulcer].

The article discusses changes in the psychological status and the forming of various types of attitude towards the disease in patients with a favorable and unfavorable course of peptic ulcer (PU). The subjects of the study were 82 patients with exacerbation of PU; among them there were 30 patients with a favorable and 52 patient with a complicated course. Patients with a favorable course of PU did not displayed prominent peaks in SMOL profile, which reflected a relatively benign state of their psychological status.

[On correlations between the clinical course of peptic ulcer and the patients, compliance and quality of life].

The article is dedicated to changes in life quality (LQ) and mental status, and to forming of various types of response to the disease in patients with benign and unfavorable course of peptic ulcer (PU). The subjects were 140 patients in acute phase of PU, in 66 of whom the course of the disease was benign, and in 74--unfavorable. In both groups there were patients with low and satisfactory LQ.

[Quality of life and vegetative status of patients with ulcer disease].

Aim: To analyse features of vegetative status of patients with ulcer disease (UD) with reference to quality of life (QL), course of UD, clinical and secretory-motor characteristics.

Material And Methods: A total of 200 UD patients were examined. UD was at the stage of exacerbation, new-onset, with a favourable or unfavourable course.

[Comparative characterization of laboratory-made selective nutrient media for Salmonella accumulation].

In this work the results of the trial of three selective nutrient media for Salmonella accumulation, viz. Leifson's selenite broth produced by the Research and Manufacturing Amalgamation (RMA) "Nutrient Media", tetrarathionate broth (Müller's medium), laboratory-prepared, and newly developed MA-broth produced by the RMA "Nutrient Media", are presented. The results of 6- and 24-hour incubation in these selective media was evaluated.

[Gastroduodenal reflex in duodenal ulcer and chronic hyperacidic gastritis].

Aim: To study motor and secretory function of the stomach and duodenum in duodenal ulcer (DU) and chronic hyperacidic gastritis (CHG).

Material And Methods: Autonomic nervous system was studied and esophagogastroduodenoscopy, 24-h intragastric pH-metry were made in 42 DU and 20 CHG patients.

Results: In comparable secretion, the patients of the above groups differed by severity and frequency of duodenogastric reflux (DGR).

[Role of duodenogastric reflus in pathogenesis of duodenal ulcer].

Duodenal ulcer is characterized by certain recurrence and occurs more often in men than in women. One can assume that functional changes, which are characterized by the seasonal nature and sex differences, play some role in its pathogenesis. There was a study of the duodenogastric reflux role in the pathogenesis of duodenal ulcer.

[Characteristic features of adaptation to experimental conditions in primates with various initial keeping conditions].

Ethological study of emotional state and behavior was carried out in male macaques of two species (Macaca mulatta and Macaca fascicularis), which were divided in three groups according to their initial keeping: isolated, family, and gregarious. During instrumental conditioning, the initial keeping was changed for identical conditions (individual caging or sitting in a primatological chair). It was shown that adaptation to stress associated with a sharp enviromental change depended on initial keeping conditions.

[Estimation of somatic, emotional, and behavioral reactions of monkeys in chronic experiments].

Long-term chronic experiments with conditioning of monkeys and biophysical and pharmacological stimulation require monitoring somatic, emotional, and behavioral reactions. To form experimental groups, it is necessary to estimate baseline psychosomatic state of a monkey. We developed a method of monitoring the functional state of Macaca monkeys and scoring state parameters.

[Dynamics of reorganization of instrumental food getting behavior of monkey under conditions of reinforcement delay].

Six adult monkeys (Macaca fascicularis) were trained to switch on a lamp by pressing the lever, to hold the lever for not less than 1 s (the lamp being switched on), and get a portion of food. After reaching a learning criterion, the delay between the lever pressing and food reinforcement was increased to 2.5 s.

[Circadian monitoring of intragastric pH in evaluation of efficiency of antisecretory therapy of duodenal ulcer].

Inhibitors of proton pump are thought "golden standard" in the treatment of ulcer. Usage of omeprasol generics in standard doses sometimes fail to adequately reduce acid production. In pain persistence in patients with duodenal ulcer receiving standard antisecretory therapy it is effective to control it with 24-h intragastric pH-metry which either indicate the necessity of dose correction or another cause of pain (concomitant affections as a rule).

[A technique for the operant conditioning to differentiate signals during reinforcement delay in primates].

A new technique of training the primates to differentiate signals immediately during execution of the instrumental act (pushing the lever) was proposed. The technique makes it possible to study the processes of decision making during activation of the executive (motor) brain systems.

[Complaints as reflection of psychic status in patients with duodenal ulcer exacerbation].

Aim: Study of relationship between leading complaints of patients with duodenal ulcer (DU) exacerbation and their psychic status, attitude to the disease and quality of life.

Materials And Methods: Psychological questionnaire surgery enrolled 94 males with endoscopically revified uncomplicated recurrence of DU.

Results: Patients complaining of dull epigastric pains only demonstrated minimal psychological changes.

[The late results in the surgical treatment of patients with arteriosclerosis obliterans of the arteries of the lower extremities].

Long-term outcomes of surgical treatment were examined in 157 patients with atherosclerosis obliterans of lower extremity arteries. Complications of an atherosclerotic process are a basic cause of death in the patients in the long-term postoperative period. More than half (53.

[The activation and inhibitory postactivation effects of chemical interoceptive stimulation under normal conditions and in experimental neurosis].

The realisation of hemointeroceptive effects was found to begin with a period of the brain activation. In normal conditions a positive correlation was found between the EEG arousal response and the concentration of mustard administered into the stomach. In experimental neurosis, both regulatory influences of the hemointeroceptive stimulation were decreased.

[Changes in the central reacting to an interoceptive signal in experimental neurosis].

The EEG arousal response to gastric distension, was studied. Neurotization reduced the response to interoceptive stimulation. This seems to be due to disturbance of the central analysis of interoceptive stimuli including the disturbance of normal activity of the activation-deactivation mechanism.

[Clinico-functional characteristics of patients with arteriosclerosis obliterans of the lower extremities and painless myocardial ischemia].

During manually performed exercise, ECG revealed silent myocardial ischemia-related ST segment depression in 62 patients with atherosclerosis obliterans in the lower limbs in the absence of evident signs of coronary abnormalities. The patients displayed decreased cardiac output, elevated total peripheral resistance, structural and functional alterations in the end blood flow system, and diminished exercise tolerance as compared to healthy subjects and atherosclerosis obliterans patients with negative loading tests. The aforementioned abnormalities were also revealed in subjects suffering from atherosclerosis obliterans in the lower limbs and documented coronary heart disease.

[The neurophysiological mechanisms of the perception of interoceptive signals].

The EEG arousal response was studied in conditions of gastric distension, the arousal response depending on the intensity of the distension. Repeated interoceptive stimuli led to the habituation. The data obtained help to better understand the mechanisms of normal and pathological types of activity of visceral systems.