Ramosin: The First Antibacterial Peptide Identified on Colombian Salamander.

The discovery and improvements of antimicrobial peptides (AMPs) have become an alternative to conventional antibiotics. They are usually small and heat-stable peptides, exhibiting inhibitory activity against Gram-negative and Gram-positive bacteria. In this way, studies on broad-spectrum AMPs found in amphibians with the remarkable capability to regenerate a wide array of tissues are of particular interest in the search for new strategies to treat multidrug-resistant bacterial strains.

Post-amputation reactive oxygen species production is necessary for axolotls limb regeneration.

Reactive oxygen species (ROS) represent molecules of great interest in the field of regenerative biology since several animal models require their production to promote and favor tissue, organ, and appendage regeneration. Recently, it has been shown that the production of ROS such as hydrogen peroxide (HO) is required for tail regeneration in . However, to date, it is unknown whether ROS production is necessary for limb regeneration in this animal model.

Hydrogen peroxide is necessary during tail regeneration in juvenile axolotl.

Background: Hydrogen peroxide (H O ) is a key reactive oxygen species (ROS) generated during appendage regeneration among vertebrates. However, its role during tail regeneration in axolotl as redox signaling molecule is unclear.

Results: Treatment with exogenous H O rescues inhibitory effects of apocynin-induced growth suppression in tail blastema cells leading to cell proliferation.