Publications by authors named "Belen Prados-Lopez"
Article Synopsis
- Two natural -kaurene diterpenoids were extracted from a plant, and six new derivatives were synthesized for evaluation of their anti-tumor properties against three types of cancer cells (colon, liver, and melanoma).
- One synthesized compound showed the strongest anti-proliferative effects across all cell lines, with a notable IC value of around 2.5 μM, and further studies indicated that some derivatives induced a selective G2/M cell cycle arrest.
- Apoptosis analysis revealed that certain compounds led to high levels of cell death (up to 99% apoptosis), linked to mitochondrial dysfunction and the activation of the intrinsic apoptotic pathway, suggesting their potential as effective anticancer agents.
Eosinophils are myeloid effector cells whose main homing is the gastrointestinal tract. There, they take part in type I and type II immune responses. They also contribute to other non-immunological homeostatic functions like mucus production, tissue regeneration, and angiogenesis.
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