Publications by authors named "Belen Martinez-Castedo"
ctDNA whole exome sequencing in pancreatic ductal adenocarcinoma unveils organ-dependent metastatic mechanisms and identifies actionable alterations in fast progressing patients.
Marisol Huerta Jorge Martín-Arana Francisco Gimeno-Valiente Juan Antonio Carbonell-Asins Blanca García-Micó
Transl Res
September 2024
Article Synopsis
- Understanding how pancreatic ductal adenocarcinoma (PDAC) progresses and developing targeted therapies is crucial, and this study involved 80 metastatic PDAC patients divided into discovery and validation groups to examine genetic variants.
- Whole exome sequencing (WES) of tumor and plasma samples highlighted that actionable mutations were more prevalent in plasma, and associations with cellular organization pathways were found in patients with shorter survival.
- Notably, KRAS mutations in plasma were linked to worse progression free survival, while significant reductions in KRAS variant allele frequency correlated with improved outcomes similar to KRAS-negative patients, emphasizing the relevance of immune response pathways in liver metastasis.