Detection of Respiratory Viruses in the Clinical Outcome of Children With Fever and Neutropenia.

Background: Several evidence-based guidelines for the management of children with febrile neutropenia (FN) have been published, with special focus in bacterial and fungal infections. However, the role of acute respiratory infections caused by respiratory viruses (RV) has not been clearly established. The aim of this study was to evaluate the epidemiology, clinical presentation and outcome of acute respiratory infections in children with FN.

Low-risk factors for severe bacterial infection and acute chest syndrome in children with sickle cell disease.

Introduction: The rate of bacterial infections in children with sickle cell disease (SCD) has decreased in recent years, mainly due to penicillin prophylaxis and vaccination.

Objectives: To determine the rate of severe bacterial infection (SBI) in a cohort of children with SCD and to describe low-risk factors for confirmed SBI (CSBI) and acute chest syndrome (ACS).

Methods: This 11-year retrospective cohort study included children with febrile SCD admitted to a reference hospital in Spain.