Publications by authors named "Belde Kasap Demir"
Background: The two strongest earthquakes in Turkey for eight decades hit Kahramanmaraş province on February 6, 2023. This study aimed to determine psychiatric complaints, acute stress symptoms, anxiety, depression, and sleep characteristics in children who were treated in a tertiary inpatient pediatric unit after the earthquakes. They were evaluated in the fourth week after the earthquake.
View Article and Find Full Text PDFPurpose: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by recurrent episodes of fever and serositis, caused by mutations in the gene. Inflammatory pathways associated with FMF are linked to increased proinflammatory cytokines, which may be related to primary headaches, including migraine. The aim of this study was to evaluate the frequency of migraine and other primary headaches in FMF patients.
View Article and Find Full Text PDFBackground: Aripiprazole-associated hypertension is a previously described side effect, but its mechanism has not been clearly elucidated. Here we present a 16-year-old male patient who developed aripiprazole-associated hypertension, and we discuss the mechanisms that may cause hypertension.
Case Diagnosis: Antipsychotic drugs are beneficial for the control of mental health conditions.
Article Synopsis
- Antenatal hydronephrosis involves swelling in a fetus's kidneys, making it crucial to differentiate between serious cases needing long-term care and those needing little intervention.
- The study compared two guidelines for managing antenatal hydronephrosis, focusing on identifying their effectiveness in various factors like detection rates, imaging requirements, and patient outcomes.
- Results showed the newer guideline led to fewer tests, reduced radiation exposure, and less need for surgical interventions compared to the older guideline.
Objectives: We aimed to report the characteristics of pediatric IgG4-related disease (IgG4-RD) through a multicentre registry, to assess disease clusters, and to evaluate the performances of the 2019 American College of Rheumatology and European League Against Rheumatism (ACR/EULAR) classification criteria and the 2020 revised comprehensive diagnostic (RCD) criteria in this cohort.
Methods: Data of IgG4-RD patients in 13 pediatric rheumatology centers were recorded to a web-based registration system. The diagnosis of IgG4-RD was made according to the 2011 comprehensive diagnostic criteria.
Objective: We aimed to evaluate the clinical significance of the "unclassified" blood pressure phenotypes on left ventricular hypertrophy in children.
Materials And Methods: All children evaluated with ambulatory blood pressure monitoring in the pediatric nephrology department between October 2018 and January 2021 were included in the study. Prehypertension, normotensive, white coat hypertension, masked hypertension, ambulatory hypertension groups and 2 other groups including increased blood pressure load, normal ambulatory blood pressure measurements, but normal (unclassified group 1) or high (unclassified group 2) office blood pressure measurements were defined according to the American Heart Association 2014 statement.
Objectives: The aim of this study is to investigate the effect of anti-interleukin (IL)-1/-6 biologics on systemic juvenile idiopathic arthritis (sJIA)-associated macrophage activation syndrome (MAS).
Methods: Demographic, clinical and laboratory data of patients followed up with a diagnosis of sJIA-associated MAS assessed from sixteen paediatric rheumatology centres across the country. The clinical and laboratory features of MAS developing while on biological drugs were compared with those without this treatment.
Article Synopsis
- Two devastating earthquakes in Türkiye on February 6, 2023, resulted in significant injuries to 903 children, with a focus on crush syndrome-related acute kidney injury (Crush-AKI) and mortality.
- The study tracked various factors, including the time under rubble, treatment protocols, and patient outcomes, revealing that Crush-AKI developed in 36% of the patients, and over half required dialysis.
- Key findings included that serum levels of creatine phosphokinase above 20,950 U/L and inadequate initial intravenous fluid volume were linked to Crush-AKI, and most deaths occurred among those with Crush-AKI within the first four days of admission.
Article Synopsis
- Immunoglobulin A vasculitis with nephritis (IgAVN) is the most common vasculitis in children, and this study aimed to analyze clinical outcomes, treatments, and risk factors in a large cohort of 1148 children diagnosed with the condition.
- The retrospective analysis revealed that poorer outcomes were associated with factors like older age, lower kidney function at onset, hypertension, and certain kidney damage features, but no specific treatment was found to be more effective than others.
- The study concluded that there is a need for further research and clinical trials to determine effective treatments and improve health outcomes for children with IgAVN.
Article Synopsis
- C3 glomerulopathy (C3G) is a kidney disease influenced by genetic factors, and this study explores the differences in clinical outcomes among pediatric patients with and without mutations in complement-related genes.
- Among 60 patients studied, 17 had genetic mutations with the CFH gene being the most common; those with mutations typically showed asymptomatic urinary issues and were diagnosed at an older age.
- Despite differences in presentation, both groups had similar long-term kidney survival and response to mycophenolate mofetil treatment, indicating that genetic mutations may not significantly impact treatment outcomes.
Background: Fatigue is a common problem in pediatric rheumatic diseases and is associated with poor quality of life. However, no validated methods are available to measure fatigue in adolescents with familial Mediterranean fever (FMF). The aim of the study was to establish validity and reliability for the child self-report PedsQL Multidimensional Fatigue Scale (PedsQL-MFS) and to investigate the effects of physical characteristics, diseaserelated characteristics, sleep quality/duration, and the amount of physical activity on fatigue in adolescents with FMF.
View Article and Find Full Text PDFPulse Wave Analysis in Obese Children with and without Metabolic Syndrome.
J Clin Res Pediatr Endocrinol
November 2023
Objective: To compare pulse wave analysis (PWA) of obese children with and without metabolic syndrome (MS) with healthy, non-obese children and to evaluate the association between PWA findings and additional risk factors present in children with MS and obesity.
Methods: From the obese patients examined between June 2019 and June 2021, 41 patients with MS, 36 obese patients without MS, and 34 healthy non-obese children of similar age and gender were evaluated retrospectively. Anthropometric measurements, biochemical evaluation, 24-hour ambulatory blood pressure (BP) measurement (ABPM), left ventricular mass index (LVMI) and PWA measurements were compared.
Article Synopsis
- The study focuses on urinary tract infections (UTIs) in children and investigates the potential use of soluble Toll-like receptors (sTLR4, sTLR5) and interleukin 8 (IL-8) as biomarkers for diagnosing UTIs.
- It involved 520 children, including those with UTIs, non-UTI infections, and healthy controls, measuring urine and serum levels of the biomarkers before and after treatment.
- Results show that urine sTLR4 levels are higher in UTI patients, with a cut-off level identified to predict UTIs, especially higher in cases of pyelonephritis compared to cystitis, and decreasing post-treatment.
Background: Alport syndrome (AS) is characterized by progressive kidney disease. There is increasing evidence that renin-angiotensin-aldosterone system (RAAS) inhibition delays chronic kidney disease (CKD) while the effectiveness of immunosuppressive (IS) therapy in AS is still uncertain. In this study, we aimed to analyze the outcomes of pediatric patients with X-linked AS (XLAS) who received RAAS inhibitors and IS therapy.
View Article and Find Full Text PDFArticle Synopsis
- - This study investigated the dietary acid load in 67 children aged 3-18 with chronic kidney disease (CKD) and its impact on their nutritional status and health-related quality of life (HRQOL).
- - Researchers found that children who were stunted or malnourished had significantly higher dietary acid loads (measured by NEAP scores), but this did not correlate with differences in HRQOL scores.
- - Key factors like waist circumference, serum albumin, and glomerular filtration rate were negatively impacted by high dietary acid loads, suggesting potential effects on children's CKD progression and nutrition.
Background: Ventricular repolarization (VR) increases the risk of sudden cardiac death due to ventricular arrhythmia. We aimed to evaluate the blood pressure (BP) parameters affecting VR in obese children.
Methods: Obese (BMI ≥ 95p) and healthy children ≥ 120 cm between January 2017 and June 2019 were included.
Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey.
Materials And Methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11 March 2020 and 11 March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry.
Aim: Urinary tract infections (UTIs) represent a common febrile illness in infancy. The study compared two UTI guidelines in terms of number of imaging studies, presence of parenchymal damage and radiation exposure in patients with the first febrile UTI between 2 and 24 months of age.
Method: The results of Tepecik UTI Guideline-1 used until 2012 (Group 1, n = 105) were retrospectively compared with Tepecik UTI Guideline-2 (Group 2) used after 2013.
Article Synopsis
- The study investigates the relationship between vesicoureteric reflux (VUR) and urinary tract infections (UTI) in children diagnosed with ureterocele, focusing on patients treated at a specific hospital over a 10-year period.
- A total of 24 children were analyzed, revealing high rates of UTI and recurrent infections, along with a notable prevalence of VUR, particularly in females.
- The findings indicate no significant difference in kidney damage or surgical needs between patients with and without VUR, highlighting the necessity for more research to guide clinical management in these cases.
Background: Patients with nephrotic syndrome (NS) are at a high risk of cardiovascular disease, obesity, and dyslipidemia. The aim of this study was to evaluate the formation of epicardial adipose tissue (EAT) and investigate electrocardiographic (ECG) parameters in patients.
Methods: Thirty-two patients aged 0-18 years and 15 control patients were compared.
Article Synopsis
- A new study looked at a special urine test called uHSP70 to help tell if kids have a urinary tract infection (UTI) instead of just using regular tests that might not be very reliable.
- The study involved 802 kids and found that uHSP70 levels were much higher in kids with UTI compared to those with other infections or who were healthy.
- Using uHSP70 could help doctors correctly diagnose UTIs and might stop about 80% of kids from getting unnecessary antibiotics.
Objective: To evaluate the effects of non-E. coli or extended-spectrum β-lactamase-positive (ESBL-positive) microorganism growth in the first febrile urinary tract infection (UTI) of infants on laboratory findings or renal parenchymal damage presenting the severity of inflammation, anatomic abnormalities defined by imaging studies, and recurrent UTIs in the follow-up period.
Methods: The data of patients aged between 2 and 24 mo and followed up for at least 6 mo with febrile UTI guideline of the authors' pediatric-nephrology clinic, were retrospectively analyzed.
Background: Chronic kidney disease (CKD) may lead to increase in serum levels of peptide hormones as a result of changes in peripheral metabolism. The pathogenesis of uremic hyperprolactinemia in CKD is not fully understood. Plasma prolactin levels are elevated in women, pubertal girls, and also in men with chronic kidney disease.
View Article and Find Full Text PDFBackground: We aimed to evaluate the predictability of extended-spectrum beta-lactamase (ESBL)-producing bacteria (PB) with inflammation markers and hemogram parameters as neutrophil-lymphocyte-ratio (NLR), platelets-lymphocyte-ratio (PLR) and mean-platelet-volume (MPV) in infants with febrile urinary tract infection until the urine cultures are resulted.
Methods: Infants between 2-24 months hospitalized for the first febrile urinary tract infections were grouped as those infected with ESBL-PB and non-ESBL-PB. The demographic and laboratory data (inflammation markers and hemogram parameters) and the ultrasonographical findings were compared between the two groups.