Turncoat antibodies unmasked in a model of autoimmune demyelination: from biology to therapy.

Autoantibodies contribute to many autoimmune diseases, yet there is no approved therapy to neutralize them selectively. A popular mouse model, experimental autoimmune encephalomyelitis (EAE), could serve to develop such a therapy, provided we can better understand the nature and importance of the autoantibodies involved. Here we report the discovery of autoantibody-secreting extrafollicular plasmablasts in EAE induced with specific myelin oligodendrocyte glycoprotein (MOG) antigens.

A unified moment tensor potential for silicon, oxygen, and silica.

Si and its oxides have been extensively explored in theoretical research due to their technological importance. Simultaneously describing interatomic interactions within both Si and SiO without the use of ab initio methods is considered challenging, given the charge transfers involved. Herein, this challenge is overcome by developing a unified machine learning interatomic potentials describing the Si/SiO/O system, based on the moment tensor potential (MTP) framework.

Endourology Fellowship: More Than a Stone's Throw Away for Women.

To characterize the trends in female representation in the endourology fellowship match compared with the urology residency match. Available deidentified match data from 2017 to 2022 was obtained from the American Urological Association and Endourology Society annual census data. We evaluated gender-specific participation in the urology residency and endourology fellowship match and compared differences in the trends over the last 6 years.

Chronically activated microglia in ALS gradually lose their immune functions and develop unconventional proteome.

Neuroinflammation and chronic activation of microglial cells are the prominent features of amyotrophic lateral sclerosis (ALS) pathology. While alterations in the mRNA profile of diseased microglia have been well documented, the actual microglia proteome remains poorly characterized. Here we performed a functional characterization together with proteome analyses of microglial cells at different stages of disease in the SOD1-G93A model of ALS.

The effect of opioid use on traffic fatalities.

We use a difference-in-differences design to study the effect of opioid use on traffic fatalities. Following Alpert et al., we focus on the 1996 introduction and marketing of OxyContin, and we examine its long-term impacts on traffic fatalities involving Schedule II drugs or heroin.

Optimization of a lipid nanoparticle-based protocol for RNA transfection into primary mononuclear phagocytes.

The effective delivery of synthetic RNA into mononuclear phagocytes is a prerequisite for experimental research and therapeutic development. However, traditional methods are highly ineffective and toxic for these cells. Here, we aimed to optimize a transfection protocol for primary bone marrow-derived phagocytes, specifically dendritic cells and macrophages, using lipid nanoparticles generated by microfluidics.

The diversity of hypospadias management in North America: a survey of pediatric urologists.

Purpose: To determine trends in hypospadias management, including surgical techniques and perioperative care, by pediatric urologists in North America.

Methods: An anonymous online survey was devised to assess approaches to hypospadias repair and management, including anesthetic considerations, catheter placement, choice of dressing, and postoperative antibiotic treatment. The survey was sent to all practicing members of the Societies for Pediatric Urology.

A Set of Moment Tensor Potentials for Zirconium with Increasing Complexity.

Machine learning force fields (MLFFs) are an increasingly popular choice for atomistic simulations due to their high fidelity and improvable nature. Here we propose a hybrid small-cell approach that combines attributes of both offline and active learning to systematically expand a quantum-mechanical (QM) database while constructing MLFFs with increasing model complexity. Our MLFFs employ the moment tensor potential formalism.

The short-term economic consequences of COVID-19: Exposure to disease, remote work and government response.

We examine the determinants of the consequences of COVID-19 on employment and wages in the United States. Guided by a pre-analysis plan, we investigate whether the economic consequences of COVID-19 were larger for certain occupations, using four indexes: workers relatively more exposed to disease, workers that work with proximity to coworkers, essential/critical workers and workers who can easily work remotely. We find that individuals that work in proximity to others are more affected while individuals able to work remotely and essential workers are less affected by the pandemic.

A Coarse-Grained Interaction Model for Sodium Dominant Montmorillonite.

Montmorillonite is the main crystalline mineral present in bentonite. It is an absorbent, swelling material; the physical chemistry underlying its ability to absorb water and swell occurs at the nanoscale, governed by electrical double-layer interactions. In turn, absorption and swelling lead to important changes in the macroscopic transport properties of the clay.

Determinants of Family Stress and Domestic Violence: Lessons from the COVID-19 Outbreak.

In this article, we examine Canadians' concerns regarding the impact of coronavirus disease 2019 (COVID-19) on domestic violence and family stress. Our empirical analysis relies on a unique survey conducted online, the Canadian Perspective Survey Series, which allows us to investigate the determinants of concerns regarding family stress and domestic violence during the first COVID-19 lockdown. We find no evidence that changes in work arrangements are related to concerns regarding family stress and violence in the home.

Lower Urinary Tract Symptoms in Young Men-Causes and Management.

Purpose Of Review: This review explores the subject of lower urinary tract symptoms (LUTS) in young men.

Recent Findings: Young men (aged 39 or younger) can be affected by a variety of conditions that can cause LUTS. Approximately half of young men report LUTS.

The short-term economic consequences of COVID-19: Occupation tasks and mental health in Canada.

In this paper, we study the effect of COVID-19 on the labour market and reported mental health of Canadians. To better understand the effect of the pandemic on the labour market, we build indexes for whether workers: (i) are relatively more exposed to disease, (ii) work in proximity to co-workers, (iii) are essential workers and (iv) can easily work remotely. Our estimates suggest that the impact of COVID-19 was significantly more severe for workers that work in proximity to co-workers and those more exposed to disease who are not in the health sector, while the effects are less severe for essential workers and workers that can work remotely.

The effect of Affordable Care Act Medicaid expansions on foster care admissions.

Recent papers have documented positive externalities of Medicaid expansions on several non-health related variables, such as crime, financial stress, child support, and child abuse. In this paper, we investigate the relationship between access to public health insurance and foster care admissions following state decisions to expand Medicaid coverage after the Affordable Care Act. Over 70% of all foster care admissions are related to child abuse incidents, which have been found to decrease following the Medicaid expansions.

Patient Safety in the Operating Room During Urologic Surgery: The OR Black Box Experience.

Purpose: To mitigate intraoperative adverse events, it is important to understand the context in which these errors occur. The purpose of this study is to characterize the IAEs and potential distractions that occur in minimally invasive urologic procedures.

Methods: We conducted a prospective cohort study in patients undergoing laparoscopic urologic surgery at an academic health center.

Microglia-derived galectin-3 in neuroinflammation; a bittersweet ligand?

Galectins are soluble β-galactoside-binding proteins found in all multicellular organisms. Galectins may act as danger-associated molecular patterns in innate immunity and/or as pattern-recognition receptors that bind to pathogen-associated molecular patterns. Among different galectin family members, galectin-3 has been the focus of studies in neurodegenerative diseases in recent years.

Immunity in amyotrophic lateral sclerosis: blurred lines between excessive inflammation and inefficient immune responses.

Despite wide genetic, environmental and clinical heterogeneity in amyotrophic lateral sclerosis, a rapidly fatal neurodegenerative disease targeting motoneurons, neuroinflammation is a common finding. It is marked by local glial activation, T cell infiltration and systemic immune system activation. The immune system has a prominent role in the pathogenesis of various chronic diseases, hence some of them, including some types of cancer, are successfully targeted by immunotherapeutic approaches.

Accelerated kinetic Monte Carlo: A case study; vacancy and dumbbell interstitial diffusion traps in concentrated solid solution alloys.

Vacancy and self-interstitial atomic diffusion coefficients in concentrated solid solution alloys can have a non-monotonic concentration dependence. Here, the kinetics of monovacancies and ⟨100⟩ dumbbell interstitials in Ni-Fe alloys are assessed using lattice kinetic Monte Carlo (kMC). The non-monotonicity is associated with superbasins, which impels using accelerated kMC methods.

Automated Detection of Helium Bubbles in Irradiated X-750.

Imaging nanoscale features using transmission electron microscopy is key to predicting and assessing the mechanical behavior of structural materials in nuclear reactors. Analyzing these micrographs is often a tedious and labour intensive manual process. It is a prime candidate for automation.

Short-Term Effect of COVID-19 on Self-Employed Workers in Canada.

Using the Canadian Labour Force Survey, we document the short-term impact of coronavirus disease 2019 (COVID-19) on self-employed individuals in Canada, whom we interpret as small business owners. We document an important decrease in business ownership between February 2020 and May 2020 (-14.8 percent for incorporated and -10.

Effect of He on the Order-Disorder Transition in Ni_{3}Al under Irradiation.

The order-disorder transition in Ni-Al alloys under irradiation represents an interplay between various reordering processes and disordering due to thermal spikes generated by incident high energy particles. Typically, ordering is enabled by diffusion of thermally generated vacancies, and can only take place at temperatures where they are mobile and in sufficiently high concentration. Here, in situ transmission electron micrographs reveal that the presence of He-usually considered to be a deleterious immiscible atom in this material-promotes reordering in Ni_{3}Al at temperatures where vacancies are not effective ordering agents.