Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation to Elucidate the Molecular Targets and Potential Mechanism of (Ajwa Dates) against Candidiasis.

Candidiasis, caused by opportunistic fungal pathogens of the genus, poses a significant threat to immunocompromised individuals. Natural compounds derived from medicinal plants have gained attention as potential sources of anti-fungal agents. Ajwa dates ( L.

Phytochemical Analysis, Antioxidant, and Antimicrobial Activities of : A Combined Experimental and Computational Approaches.

Boiss. is a rare desert plant known to be a promising source of bioactive compounds. In this paper, we report for the first time the phytochemical composition and biological activities of hydroalcoholic extract by using liquid chromatography-electrospray tandem mass spectrometry (ESI-MS/MS) technique.

Element concentration, daily intake of elements, and health risk indices of wild mushrooms collected from Belgrad Forest and Ilgaz Mountain National Park (Turkey).

The aim of this study was to determine the element content of wild edible and inedible mushroom species (Agaricus campestris, Armillaria ostoyae, Boletus reticulatus, Bondarzewia mesenterica, Bovistella utriformis, Cantharellus cibarius, Marasmius oreades, Megacollybia platyphylla, Meripilus giganteus, Neoboletus erythropus, Panellus stipticus, Phaeotremella foliacea, Pleurotus ostreatus, Podoscypha multizonata, Russula aurea, R. chloroides, R. virescens, T.

Metal concentrations of wild mushroom species collected from Belgrad forest (Istanbul, Turkey) with their health risk assessments.

Wild edible mushrooms are very popular for both their flavors and nutritional values. However, some mushroom species can be harmful to human health as they accumulate some elements in excessive amounts. The aim of this study was to determine the concentrations of Al, Ca, Cd, Cr, Cu, Fe, K, Mg, Mn, P, Se, and Zn of some wild edible (Agaricus arvensis, A.

Evaluation of the metal concentrations of wild mushroom species with their health risk assessments.

The ability of mushrooms to accumulate heavy metals has increased concerns over their toxic effects on human health in recent years. The aim of this study was to determine the metal contents (Zn, Fe, Co, Mn, Cu, Pb, Ni, and Cd), daily intake of metal (DIM) and health risk index (HRI) values of nineteen different mushroom species (edible, inedible, and poisonous) collected from Uzungol, Trabzon (Turkey). Although the area where mushrooms were collected has the status of "Natural Park," there has been an excessive human settlement in recent years.

Campanula macrostachya: biological activity and identification of phenolics using a liquid chromatography electrospray ionization tandem mass spectrometry system.

It is known that some Campanula species are traditionally used because of their anti-allergic, spasmolytic, antiphlogistic, antioxidant, and antiviral properties. This study was designed to evaluate the phytochemical composition, antioxidant, α-amylase, and tyrosinase inhibitory activity of ethyl acetate, methanol, and water extracts of Campanula macrostachya Waldst. & Kit.

Metal concentration and health risk assessment of eight Russula mushrooms collected from Kizilcahamam-Ankara, Turkey.

The aim of this study was to determine the essential element (Zn, Ca, K, Fe, Na, and Mg), essential trace element (Co, Mn, Cr, and Cu), and non-essential element (Pb, Ni, and Cd) contents of eight different Russula species (R. risigallina (Batsch) Sacc., R.

analysis of the interactions of certain flavonoids with the receptor-binding domain of 2019 novel coronavirus and cellular proteases and their pharmacokinetic properties.

Coronavirus Disease 2019 (COVID-19) has infected more than thirty five million people worldwide and caused nearly 1 million deaths as of October 2020. The microorganism causing COVID-19 was named as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 or 2019-nCoV). The aim of this study was to investigate the interactions of twenty-three phytochemicals belonging to different flavonoid subgroups with the receptor binding domain (RBD) of the spike glycoprotein of 2019-nCoV, and cellular proteases [transmembrane serine protease 2 (TMPRSS2), cathepsin B and L (CatB/L)].

Interaction of certain monoterpenoid hydrocarbons with the receptor binding domain of 2019 novel coronavirus (2019-nCoV), transmembrane serine protease 2 (TMPRSS2), cathepsin B, and cathepsin L (CatB/L) and their pharmacokinetic properties.

As of June 2020, the coronavirus disease 19 (COVID-19) caused by the 2019 new type coronavirus (2019-nCoV) infected more than 7,000,000 people worldwide and caused the death of more than 400,000 people. The aim of this study was to investigate the molecular interactions between monoterpenoids and spike protein of 2019-nCoV together with the cellular proteases [transmembrane serine protease 2 (TMPRSS2), cathepsin B (CatB), and cathepsin L (CatL)]. As a result of the relative binding capacity index (RBCI) analysis, carvone was found to be the most effective molecule against all targets when binding energy and predicted (theoretical) IC50 data were evaluated together.

Metal concentration and health risk assessment of fifteen wild mushrooms collected from the Ankara University Campus (Turkey).

The aim of this study is to analyze Fe, Mn, Cu, Zn, Co, Cd, Pb, and Ni contents of Cyclocybe cylindracea, Armillaria mellea, Bjerkandera adusta, Rheubarbariboletus armeniacus, Coprinellus disseminatus, C. micaceus, C. comatus, Inonotus hispidus, Lepista nuda, Leucoagaricus leucothites, Pleurotus ostreatus, Cerioporus squamosus, Schizophyllum commune, Scleroderma verrucosum, and Trametes trogii collected from the Ankara University Besevler 10th Year Campus (Turkey), an area where human settlement and traffic are intense.

Enzyme and Biological Activities of the Water Extracts from the Plants , and That Are Used as Folk Remedies in Turkey.

Phenolic compounds are secondary metabolites that are found ubiquitously in plants, fruits, and vegetables. Many studies have shown that regular consumption of these compounds could have a positive effect on our health. The aim of this study was to compare the phytochemical contents of the water extracts from three different plants used as folk remedies in Turkey: , , and .

Phenolic composition, enzyme inhibitory, and antioxidant activity of .

This study aimed to evaluate the antioxidant and enzyme inhibitory activities of ethyl acetate, methanol, and water extracts of . In phosphomolybdenum assay, the methanol extract showed the highest activity (166.78 μmol TEs/g dry plant).

Chemical composition, antioxidant, and enzyme inhibitory activities of the essential oils of three species as well as their fatty acid compositions.

This study aimed to investigate the chemical composition, antioxidant, and enzyme inhibitory activities of the essential oils of WILLD., L., and WILLD.

Inhibitory effect of Zataria multiflora Boiss. essential oil, alone and in combination with monolaurin, on Listeria monocytogenes.

Listeria monocytogenes is one of the major causes of infections in developing countries. In this study, chemical composition and anti-listerial effect of the essential oil of Zataria multiflora Boiss. alone and in combination with monolaurin were evaluated at different pH values (5, 6, and 7) and temperatures (5 ˚C and 30 ˚C).

Medicinal Uses, Phytochemistry, and Pharmacology of Origanum onites (L.): A Review.

Origanum onites L., known as Turkish oregano, has great traditional, medicinal, preservative, and commercial importance. It is used for the treatment of several kinds of ailments, such as gastrointestinal disorders, diabetes, high cholesterol, leukemia, bronchitis, etc.

Effect of Capparis spinosa L. on cognitive impairment induced by D-galactose in mice via inhibition of oxidative stress.

Background/aim: To determine the phenolic acid levels and DNA damage protection potential of Capparis spinosa L. seed extract and to investigate the effect of the extract on cognitive impairment and oxidative stress in an Alzheimer disease mice model.

Materials And Methods: Thirty BALB/c mice divided into 5 groups (control, D-galactose, D-galactose + C.

Phenolic Acid Composition and Anti-Parasitic Effects of Four Peucedanum Species on Entamoeba histolytica Trophozoites.

Background: The aim of this study was to determine phenolic acid composition and anti-parasitic effects of Peucedanum caucasicum, P. palimbioides, P. longibracteolatum and P.

Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of D-galactose-induced aging mice.

Context: Morus nigra L. (Moraceae) has various uses in traditional medicine. However, the effect of M.

A pharmacological and phytochemical overview on Satureja.

Context: Satureja (Lamiaceae) species are used as flavoring compounds in food, pharmaceutical, and cosmetic industries because of its sweetness and simple cultivation characteristics. They have traditionally been used as muscle pain relievers, tonic, and carminative agents to treat stomach and intestinal disorders such as cramps, nausea, indigestion, and diarrhea, due to their considerable phytochemical characteristics.

Objective: This review evaluates some information published since 1989 on Satureja genus from a systematic perspective in terms of its pharmacological and phytochemical characteristics.

Metal concentration and antioxidant activity of edible mushrooms from Turkey.

This study presents information on the antioxidant activity and heavy metal concentrations of Polyporus sulphureus, Macrolepiota procera, Lycoperdon perlatum and Gomphus clavatus mushrooms collected from the province of Mugla in the South-Aegean Region of Turkey. Antioxidant activities of mushroom samples were evaluated by four complementary tests. All tests showed L.