Publications by authors named "Beke Kolms"
Article Synopsis
- Thyroid hormones play a crucial role in regulating body temperature and energy metabolism, with medical conditions like hyperthyroidism and hypothyroidism directly affecting these processes.
- Recent research highlights the roles of specific thyroid hormone receptors, particularly TRα1 and TRβ, in body temperature regulation, although the exact functions and brain areas involved are still unclear.
- Experiments using mutant TRα1 mice and TRβ knockouts showed that TRα1 is vital for maintaining body temperature, with T3 treatment being effective in normalizing temperature in mutant mice, indicating it's crucial for setting the central temperature in the hypothalamus.
Article Synopsis
- Maternal thyroid hormones significantly influence fetal development, but the effects of maternal hyperthyroidism on offspring are not well understood.
- In a mouse study, maternal treatment with the thyroid hormone T3 during pregnancy improved glucose tolerance in male offspring and increased thermogenesis in brown adipose tissue (BAT) in both sexes.
- The study found that proper maternal thyroid hormone receptor β (TRβ) signaling is crucial for these benefits, and alterations in maternal serum metabolites like choline were also observed, linking maternal TRβ activation to specific adaptations in offspring thermoregulation.
Parkinson's disease (PD) is a progressive neurodegenerative disorder. Genetic modifiers, environmental factors and gene-environment interactions have been found to modify PD risk and disease progression. The objective of this study was to evaluate the association of smoking, caffeine and anti-inflammatory drugs with age at onset (AAO) in a large PD cohort.
View Article and Find Full Text PDFA gradual adaptation to a shifted light-dark (LD) cycle is a key element of the circadian clock system and believed to be controlled by the central circadian pacemaker, the (SCN). Endocrine factors have a strong influence on the regulation of the circadian clock network and alter acute photic responses of the SCN clock. In females, endocrine function depends on the stage of the ovarian cycle.
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