Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium.

Aging epithelia are colonized by somatic mutations, which are subjected to selection influenced by intrinsic and extrinsic factors. The lack of suitable culture systems has slowed the study of this and other long-term biological processes. Here, we describe epithelioids, a facile, cost-effective method of culturing multiple mouse and human epithelia.

Study of the correlation between the magnetic and electrical properties of the LaSrMnO compound.

In this work, we investigated the relationship between the electrical and magnetic properties of the superparamagnetic (SPM) LaSrMnO (S1C0) compound prepared by the sol-gel method. The (S1C0) sample displayed a ferromagnetic metallic (FMM) behavior at low temperatures and a paramagnetic semiconductor (PMSC) behavior at high temperatures. The FMM behavior was described by the Zener Double Exchange (ZDE) polynomial law containing the contributions of the electron-electron (e-e) interactions and the electron-magnon (e-m) scattering.

Synthesis, characterization, and sensitivity tests of LaBaBiFeO nanoparticles towards a few parts-per-billion of acetone gas.

In the present paper, the powders were synthesized via the auto-combustion method. The optical, the positron annihilation spectroscopy and the gas sensing properties of our sample were investigated simultaneously. FTIR spectrum revealed the antisymmetric deformation vibrations of the Fe-O and Fe-O-Fe bonds inside the octahedron FeO.

Crosstalk of human coronary perivascular adipose-derived stem cells with vascular cells: role of tissue factor.

The coronary perivascular adipose tissue (cPVAT) has been associated to the burden of cardiovascular risk factors and to the underlying vessel atherosclerotic plaque severity. Although the "outside to inside" hypothesis of PVAT-derived-adipokine regulation of vessel function is currently accepted, whether the resident mesenchymal stem cells (ASCs) in PVAT have a regulatory role on the underlying vascular arterial smooth muscle cells (VSMCs) is not known. Here, we investigated the interactions between resident PVAT-ASCs and VSMCs.

Sediment recontamination potential and biological impacts of hydrophobic organics from stormwater in a mixed-use watershed.

This study focused on understanding the influence of stormwater on sediment recontamination and biota bioaccumulation. Stormwater and sediment sampling was conducted at Paleta Creek San Diego, CA, a mixed-use urban watershed. Stormwater samples were size fractioned into clay, silt, sand, and filtered fractions to better understand the association of PAHs and PCBs with different particle sizes.

Evaluation of a high resolution diode array for CyberKnife quality assurance.

Purpose: The CyberKnife quality assurance (QA) program relies mainly on the use of radiochromic film (RCF). We aimed at evaluating high-resolution arrays of detectors as an alternative to films for CyberKnife machine QA.

Methods: This study will test the SRS Mapcheck (Sun Nuclear, Melbourne, Florida, USA) diode array and its own software, which allows three tests of the CyberKnife QA program to be performed.

The use of a thin guide-wire for urethral definition in prostate SBRT treatments with Cyberknife.

Purpose: To study and analyze the effect of the use of a thin guide-wire instead of a Foley catheter for urethral definition in prostate stereotactic body radiation therapy (SBRT) treatments and to compare treatment parameters in both situations.

Material And Methods: Thirty-seven prostate SBRT patients were employed in this study. A Foley catheter was employed in nine of them, and a guide-wire was employed in the other 28 patients.

Stress, anxiety, and depression among students at the Faculty of Medicine of Sousse (Tunisia).

Objective: To evaluate the frequency of anxious and depressive symptoms and to determine their associated factors in a population of students enrolled at the Faculty of Medicine of Sousse (Tunisia).

Methods: this is a descriptive cross-sectional study that took place at the Faculty of Medicine of Sousse over the period from 09/15/2017 to 03/15/2018. An anonymous questionnaire was administered to the students in the guided teaching rooms.

Structural, morphological, Raman, dielectric and electrical properties of La Ba Bi FeO (0.00 ≤ ≤ 0.20) compounds.

La Ba Bi FeO (0.00 ≤ ≤ 0.20) nanoparticles were prepared by the auto-combustion method using glycine as a combustion fuel.

Investigation of temperature and frequency dependence of the dielectric properties of multiferroic (LaCa)BiFeO nanoparticles for energy storage application.

In this work we synthesized the multifunctional (LaCa)BiFeO material using a sol-gel process. Structural and morphologic investigations reveal a perovskite structure at room temperature with spherical and polygonal nanoparticles. A detailed study of the temperature dependence of the dielectric and electrical properties of the studied material proves a typical FE-PE transition with a colossal value of real permittivity at 350 K that allows the use of this material in energy storage devices.

Prognostic value of atrial strain in non-ischemic dilated cardiomyopathy.

Introduction: Left atrial function in non-ischemic dilated cardiomyopathy (DCM) has long been underestimated when studying the ultrasound parameters of DCM. Currently, several ultrasound parameters of left atrial function have been proposed as markers to detect patients at risk.

Aim: To evaluate the left atriumfunctionwith 2D speckle tracking echocardiography and itsprognostic value in the dilatedcardiomyopathy.

Assessing Biota Accumulation Due to Contamination of Sediments by Storm Water Heavy Metals.

Evaluating sediment recontamination due to storm water discharges is important when evaluating the long-term effectiveness of sediment remediation efforts at reducing biological impacts. The bioaccumulation of the heavy metals zinc, nickel, copper, cadmium, mercury, and lead and the metalloid arsenic in a clam (Macoma nasuta) was studied in surficial sediments before and after storm water inputs from Paleta Creek, California, USA, during wet seasons in 2015 to 2016 and 2016 to 2017. The bioaccumulation was compared with bulk sediment concentrations and porewater concentrations measured by diffusion gradient in thin film devices.

Effect of Bi-substitution into the A-site of multiferroic LaCaFeO on structural, electrical and dielectric properties.

(LaCa) Bi FeO ( = 0.00, 0.05, 0.

Dosimetric and Contrast Noise Ratio Comparison of Three Different Digital Imaging Technologies in Mammography.

Purpose: The purpose of the study was to compare the three most common technologies available in digital mammography based in the evaluation of average glandular dose and contrast noise ratio (CNR).

Method: The average glandular dose was estimated with a direct digital detector (aSe) with a pixel size of 0.85 μm, a photon counter with a pixel size of 50 μm and a computerized radiography (CR) system.

Stem cells from human cardiac adipose tissue depots show different gene expression and functional capacities.

Background: The composition and function of the adipose tissue covering the heart are poorly known. In this study, we have investigated the epicardial adipose tissue (EAT) covering the cardiac ventricular muscle and the EAT covering the left anterior descending artery (LAD) on the human heart, to identify their resident stem cell functional activity.

Methods: EAT covering the cardiac ventricular muscle was isolated from the apex (avoiding areas irrigated by major vessels) of the heart (ventricular myocardium adipose tissue (VMAT)) and from the area covering the epicardial arterial sulcus of the LAD (PVAT) in human hearts excised during heart transplant surgery.

On the use of Bayesian statistics in the application of adaptive setup protocols in radiotherapy.

Purpose: To propose adaptive setup protocols using Bayesian statistics that facilitate, based on a prediction of coverage probability, making a decision on which patients should follow daily imaging prior to treatment delivery.

Materials And Methods: The suitability of the treatment margins was assessed combining interfraction variability measurements of the first days of treatment with previous data gathered from our patient population. From this information, we decided if a patient needs an online imaging protocol to perform daily isocenter correction before each treatment fraction.

Athletic Trainers' Influence on National Collegiate Athletic Association Division I Athletes' Basic Psychological Needs During Sport Injury Rehabilitation.

Context: Athletic trainers (ATs) have indicated a desire to better understand the motivations of athletes during rehabilitation. Self-determination theory offers an ideal lens for conceptualizing the antecedents, mediators, and consequences of motivated behavior.

Objective: To explore athletes' perceptions of ATs' influence on their basic psychological needs as well as their motivation during sport injury rehabilitation.

10-MV SBRT FFF IRRADIATION TECHNIQUE IS ASSOCIATED TO THE LOWEST PERIPHERAL DOSE: THE OUTCOME OF 142 TREATMENT PLANS FOR THE 10 MOST COMMON TUMOUR LOCATIONS.

There is a growing interest in the combined use of Stereotactic Body Radiation Therapy (SBRT) with Flattening Filter Free (FFF) due to the high local control rates and reduced treatment times, compared to conventionally fractionated treatments. It has been suggested that they may also provide a better radiation protection to radiotherapy patients as a consequence of the expected decrease in peripheral doses. This work aims to determine this reduction in unattended out-of-field regions, where no CT information is available but an important percentage of second primary cancers occur.

Silybum marianum provides cardioprotection and limits adverse remodeling post-myocardial infarction by mitigating oxidative stress and reactive fibrosis.

Aims: Milk thistle (Silybum marianum; SM) is an herb commonly used for hepatoprotection with antioxidant and antifibrotic properties. We investigated in pigs the cardiac effects of SM intake during the acute phase of myocardial infarction (MI) and remodeling period post-MI.

Methods: Study-1 tested the effect of SM use on the acute phase of MI.

Toward the enhancement of sensory profile of sausage "Merguez" with chickpea protein concentrate.

The influence of different Chickpea Protein Concentrates (CPC) addition at different levels (CPC: 1.5, 2.5 and 5% (w/w)) on physico-chemical, textural and hedonic properties of formulated and cooked sausage "Merguez" were investigated.

Magnetocaloric study, critical behavior and spontaneous magnetization estimation in LaCaSrMnO perovskite.

A detailed study of structural, magnetic and magnetocaloric properties of the polycrystalline manganite LaCaSrMnO is presented. The Rietveld refinement of X-ray diffraction pattern reveals that our sample is indexed in the orthorhombic structure with space group. Magnetic measurements display a second order paramagnetic (PM)/ferromagnetic (FM) phase transition at Curie temperature = 304 K.

Detrimental Effect of Hypercholesterolemia on High-Density Lipoprotein Particle Remodeling in Pigs.

Background: Beneficial effects of high-density lipoproteins (HDL) seem altered in patients with symptomatic cardiovascular disease. We recently demonstrated in a swine model of ischemia-reperfusion (IR) that hypercholesterolemia abolishes HDL-related cardioprotection.

Objectives: This study sought to investigate, using the same animal model, whether the reported impairment of HDL cardioprotective function was associated with alterations in HDL remodeling and functionality.

Allogenic adipose-derived stem cell therapy overcomes ischemia-induced microvessel rarefaction in the myocardium: systems biology study.

Background: Myocardial microvascular loss after myocardial infarction (MI) remains a therapeutic challenge. Autologous stem cell therapy was considered as an alternative; however, it has shown modest benefits due to the impairing effects of cardiovascular risk factors on stem cells. Allogenic adipose-derived stem cells (ASCs) may overcome such limitations, and because of their low immunogenicity and paracrine potential may be good candidates for cell therapy.