Synopsis of recent research by authors named "Beiyuan Liang"
- Beiyuan Liang's recent research focuses on the cGAS/STING signaling pathway and its implications in enhancing immune responses in colorectal cancer treatments, particularly in conjunction with chemotherapy agents like 5-FU and oxaliplatin.
- His studies indicate that these chemotherapy drugs not only induce DNA damage but also activate the cGAS/STING pathway, leading to increased expression of interferon and PD-L1, which complicates T cell anti-tumor activity.
- Additionally, Liang explores the potential of riluzole to augment anti-PD-1 efficacy by increasing intratumoral T cells and regulating key immune signaling components, highlighting the importance of the STING expression, which is influenced by factors like SIX4 in colorectal cancer.
