Publications by authors named "Beixuan Zheng"
Purpose: Microvascular invasion (MVI) serves as a significant predictor of poor prognosis in intrahepatic cholangiocarcinoma (ICC). This study aims to establish a comprehensive model utilizing MR radiomics for preoperative MVI status stratification and outcome prediction in ICC patients.
Materials And Methods: A total of 249 ICC patients were randomly assigned to training and validation cohorts (174:75), along with a time-independent test cohort consisting of 47 ICC patients.
Objectives: To establish an MRI-based model for microvascular invasion (MVI) prediction in mass-forming intrahepatic cholangiocarcinoma (MF-iCCA) and further evaluate its potential survival and therapeutic benefit.
Methods: One hundred and fifty-six pathologically confirmed MF-iCCAs with traditional surgery (121 in training and 35 in validation cohorts), 33 with neoadjuvant treatment and 57 with first-line systemic therapy were retrospectively included. Univariate and multivariate regression analyses were performed to identify the independent predictors for MVI in the traditional surgery group, and an MVI-predictive model was constructed.
Article Synopsis
- A predictive model using MRI has been developed to forecast postoperative recurrence in intrahepatic cholangiocarcinoma (iCCA), providing insights for treatment direction concerning neoadjuvant and adjuvant therapies.
- Analysis of 114 patients revealed that factors like tumor multiplicity, hemorrhage, hyperintensity around the tumor, and positive lymph nodes were significantly related to recurrence, helping to shape the recurrence prediction model.
- The model's effectiveness was demonstrated with good area under the curve values for 1-year and 2-year predictions, indicating that MRI can help identify high-risk patients who may benefit from targeted therapies.
Article Synopsis
- The study aimed to find a way to identify intrahepatic cholangiocarcinoma (iCCA) patients at high risk for early recurrence (ER) using preoperative MRI, focusing on diffusion-weighted imaging.
- It included 175 iCCA patients and found that tumor apparent diffusion coefficient (ADC) was a strong predictor of ER, with an optimal threshold identified at 1.273 × 10 mm/s.
- The findings suggest that preoperative MRI, particularly analyzing ADC, can be effectively used to predict ER in iCCA patients, offering insights comparable to the current AJCC staging system.
Purpose: To investigate the significance of the predominant component of combined hepatocellular-cholangiocarcinoma (cHCC-CC) in terms of MRI manifestation and its potential prognostic value compared to hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).
Materials And Methods: A total of 300 patients with chronic liver disease from two centers were retrospectively enrolled, including 100 surgically proven cases of cHCC-CC, HCC, and ICC each. Univariate and multivariate regression analyses were performed to identify independent predictors for distinguishing HCC-predominant cHCC-CC and ICC-predominant cHCC-CC from HCC and ICC, respectively.