Synopsis of recent research by authors named "Beisi Xu"
- Beisi Xu's recent research primarily focuses on understanding the molecular mechanisms underlying genetic regulation in cancer and neurodevelopment, highlighting the role of proteins such as 53BP1, PHF6, and the impact of super-enhancers in these processes.
- Key findings demonstrate that phosphorylation of 53BP1 by ATM is essential for neural development, while loss-of-function mutations in MGA affect transcriptional regulation in acute myeloid leukemia, showcasing the intricate relationships between gene expression and disease.
- Xu has also explored novel techniques, such as ConVERGD for targeting specific neuronal subtypes, and investigated RNA modifications in splicing regulation, emphasizing the importance of chromatin interactions and post-transcriptional modifications in cellular processes and disease states.
