Publications by authors named "Beirong Gao"
Gastric cancer is the second leading cause of death from cancer worldwide, with an approximately 20% 5-year survival rate. To identify molecular subtypes associated with the clinical prognosis, in addition to genetic aberrations for potential targeted therapeutics, we conducted a comprehensive whole-genome analysis of 131 Chinese gastric cancer tissue specimens using whole-genome array comparative genomic hybridization. The analyses revealed gene focal amplifications, including CTSB, PRKCI, PAK1, STARD13, KRAS, and ABCC4, in addition to ERBB2, FGFR2, and MET.
View Article and Find Full Text PDFPurpose: FGFR gene aberrations are associated with tumor growth and survival. We explored the role of FGFR2 amplification in gastric cancer and the therapeutic potential of AZD4547, a potent and selective ATP-competitive receptor tyrosine kinase inhibitor of fibroblast growth factor receptor (FGFR)1-3, in patients with FGFR2-amplified gastric cancer.
Experimental Design: Array-comparative genomic hybridization and FISH were used to identify FGFR2 amplification in gastric cancer patient tumor samples.
Article Synopsis
- AKT is a crucial component in cancer signaling networks, and AZD5363 is a new compound that effectively inhibits all AKT isoforms at low concentrations.
- AZD5363 has been shown to reduce tumor cell growth in a variety of cancer types, particularly in breast cancer, and its effectiveness is influenced by specific genetic mutations (like PIK3CA and PTEN).
- Chronic oral administration of AZD5363 in mice demonstrated dose-dependent tumor growth inhibition and increased effectiveness when combined with other cancer treatments, highlighting its potential for clinical use and personalized medicine strategies.
Nitric oxide ((.-)NO) is an important physiological signaling molecule and potent vasodilator. Recently, we have shown abnormal (.
View Article and Find Full Text PDF