Aureoterrolides B‒M: Eremophilane-type sesquiterpenoids isolated from Aspergillus aureoterreus and their cytotoxicity.

Uncovered by genome sequence analyses, twelve undescribed sesquiterpenoids designated aureoterrolides B‒M, were isolated from the culture broth of the fungus Aspergillus aureoterreus together with two known analogues. They are unusual eremophilanes with an oxidized C-4, of which aureoterrolide J is an unreported furanoeremophilane comprising a 3/6/6/5/3 pentacyclic architecture with a rare 3,6-spiro ring system. Their structures and absolute configurations were unambiguously assigned by extensive spectroscopic method and theoretical ECD calculation.

Two new -pyrone-containing polyketides isolated from the fungus .

Two undescribed -pyrone-containing polyketide derivatives designated aurovertins V () and W (), and a known analogue (), were isolated from the fungus . Their structures including the absolute configuration were elucidated on the basis of extensive spectroscopic methods and theoretical ECD calculation. Compound is the first example of aurovertins with a 7 configuration, whereas comprises a configuration for C-6 and a geometry of the double bond Δ.