Publications by authors named "Beiling Li"

Background: The model for end-stage liver disease (MELD) score is widely used for the prognostication in end-stage liver disease but has limited performance in acute-on-chronic liver failure (ACLF). In this study, we identified additional predictive parameters and reformed the MELD score to predict ACLF more accurately.

Methods: A meta-analysis was performed on relevant studies to identify the predictive factors of 28-day/90-day outcomes of ACLF, which were validated in two large prospective cohorts.

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Background & Aims: Acute-on-chronic liver failure (ACLF) is a complex syndrome with limited treatment options. This study aims to investigate the impact of artificial liver support system (ALSS) on the one-year prognosis of patients with Hepatitis B virus (HBV)-associated ACLF.

Method: A retrospective study was conducted on 239 patients with HBV-ACLF in Nanfang Hospital from January 2016 to June 2021.

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Article Synopsis
  • The study focused on finding predictive factors and developing prognostic models for acute-on-chronic liver disease (AoCLD) caused by hepatitis B virus and alcohol consumption.
  • Two nomograms, CATCH-LIFE A and CATCH-LIFE B, were created using data from two cohorts, showing strong abilities to predict 28-day and 90-day mortality rates.
  • These nomograms can help in identifying high- and low-risk patients, potentially improving treatment strategies and survival outcomes for AoCLD patients.
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  • Acute-on-chronic liver disease (AoCLD) is a major cause of hospitalization in hepatology, prompting a study to better understand its characteristics for diagnosis and prognosis.
  • A total of 3,375 patients were analyzed, highlighting that liver cirrhosis acute decompensation (LC-AD) is the most common type, with hepatitis B virus (HBV) being the leading cause of chronic liver disease.
  • The study revealed high mortality rates associated with AoCLD subtypes, emphasizing that bacterial infections are significant precipitating factors and that timely medical intervention is crucial for improving patient outcomes.
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Background And Aims: Acute-on-chronic liver failure (ACLF) is a highly dynamic syndrome. The objective of this study was to delineate the clinical course of patients with HBV-ACLF and to develop a model to estimate the temporal evolution of disease severity.

Methods: We enrolled eligible patients from 2 large, multicenter prospective cohorts.

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  • - The study aimed to explore how common anemia is in patients with cirrhosis experiencing acute decompensation or liver injury and its impact on patient outcomes.
  • - Out of 1,979 patients analyzed, 70.2% were found to have anemia, with varying severities, and a significant link was established between lower hemoglobin levels and higher mortality risks over 90 days and 1 year.
  • - The findings highlighted that severe anemia is a strong predictor of worse survival rates after 28 days, indicating the need for monitoring and management in these patients.
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  • Acute-on-chronic liver failure (ACLF), particularly due to chronic hepatitis B, poses a significant risk of mortality among patients, especially in Asia; researchers aimed to identify biomarkers to improve diagnosis and prognosis.
  • A study involving over 1,000 plasma samples from patients with HBV-related liver issues utilized metabolomics to discover metabolites linked to 90-day mortality and the progression to ACLF.
  • The findings led to the development of diagnostic algorithms with high accuracy, showing promise for clinical use through targeted assays, thus enhancing the management of HBV-related ACLF patients.
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Background And Aims: Approximately 10% of patients with acute decompensated (AD) cirrhosis develop acute-on-chronic liver failure (ACLF) within 28 days. Such cases have high mortality and are difficult to predict. Therefore, we aimed to establish and validate an algorithm to identify these patients on hospitalization.

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Background: The accurate prediction of the outcome of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is impeded by population heterogeneity. The study aimed to assess the impact of underlying cirrhosis on the performance of clinical prediction models (CPMs).

Methods: Using data from two multicenter, prospective cohorts of patients with HBV-ACLF, the discrimination, calibration, and clinical benefit were assessed for CPMs predicting 28-day and 90-day outcomes in patients with cirrhosis and those without, respectively.

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Background And Aims: The accuracy of model for end-stage liver disease (MELD) and MELD with sodium (MELD-Na) scores in reflecting the clinical outcomes of patients with cirrhosis and portal vein thrombosis (PVT) remains unclear. This study aimed to evaluate the performance of scores in predicting 90-day mortality in patients with cirrhosis and PVT.

Methods: Post hoc analysis was performed in two prospective cohorts (NCT02457637 and NCT03641872).

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Background & Aims: Although the effect of bacterial infection on cirrhosis has been well-described, the effect of non-hepatotropic virus (NHV) infection is unknown. This study evaluated the genome fragments of circulating microorganisms using metagenomic next-generation sequencing (mNGS) in individuals with acute decompensation (AD) of cirrhosis, focusing on NHVs, and related the findings to clinical outcomes.

Methods: Plasma mNGS was performed in 129 individuals with AD of cirrhosis in the study cohort.

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Article Synopsis
  • Autoimmune liver disease (AILD) has been found to have a prevalence of 9.3% among cirrhotic patients in China suffering from acute decompensation (AD), based on a study of nearly 2,600 patients.
  • The study revealed that patients with AILD experienced a significantly lower rate of acute-on-chronic liver failure (ACLF) compared to those with cirrhosis from other causes, with 28-day and 90-day mortality rates in AILD-related ACLF patients being 43.8% and 80%, respectively.
  • Key risk factors for increased mortality within 90 days included total bilirubin levels, hepatic encephalopathy, and blood urea nitrogen, while the specific type of
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The acute-on-chronic liver failure (ACLF) development is highly dynamic. Currently, no satisfactory algorithm identifies patients with HBV at risk of this complication. The aim of the study was to characterize ACLF development in hospitalized HBV-related patients without previous decompensation and to test the performance of traditional prognostic models in ruling out ACLF development within 28 days on admission we conducted a cohort study.

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Background & Aims: Pre-acute-on-chronic liver failure (ACLF) is a distinct intermediate stage between acute decompensation (AD) and ACLF. However, identifying patients with pre-ACLF and predicting progression from AD to ACLF is difficult. This study aimed to identify pre-ACLF within 28 days, and to develop and validate a prediction model for ACLF in patients with HBV-related decompensated cirrhosis.

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Background And Aims: Hepatitis B virus (HBV) reactivation is a serious condition and has been extensively described in chemotherapeutic immunosuppressive population. However, little is known about HBV reactivation in immunocompetent patients with chronic hepatitis B (CHB). In this study, we evaluated the prevalence and the clinical significance of HBV reactivation in CHB patients with acute exacerbations.

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Background: No reports exist regarding the prevalence of different Na levels and their relationship with 90-day prognosis in hospitalized patients with acute-on-chronic liver disease (AoCLD) in China. Therefore, the benefit of hyponatremia correction in AoCLD patients remains unclear.

Methods: We prospectively collected the data of 3970 patients with AoCLD from the CATCH-LIFE cohort in China.

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Hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) is a complicated syndrome with extremely high short-term mortality. Whether plasma exchange (PE) improves HBV-ACLF outcomes remains controversial. Here, PE-based non-bioartificial liver support system (NB-ALSS) effects on short-term HBV-ACLF patient outcomes were investigated.

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Article Synopsis
  • The study investigates how the international normalized ratio (INR) affects mortality rates in patients with cirrhosis and advanced fibrosis, finding a correlation between higher INR levels and increased risk of death.
  • Over 3,400 patients were analyzed, revealing a 90-day LT-free mortality rate of 16.7% for cirrhosis patients and 7.5% for those with advanced fibrosis.
  • Key findings show that an INR increase is strongly linked to short-term mortality risk, with critical INR thresholds identified as starting points for rapid increases in mortality.
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Empirical antibiotic therapy in patients with spontaneous bacterial peritonitis (SBP) is common as pathogen(s) are identified in only 5%-20% patients using conventional culture-based techniques. Metagenome next-generation sequencing (mNGS) test is a promising approach for the diagnosis of infectious disease. The clinical application of mNGS for infected ascites in cirrhotic patients is rarely reported.

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Patients with cirrhosis have an increased risk of short-term mortality, however, few studies quantify the association between neutrophil-to-lymphocyte ratio (NLR) and 90-day transplant-free mortality in cirrhotic patients. We prospectively analyzed 3,970 patients with chronic liver diseases from two multicenter cohorts in China (January 2015 to December 2016 and July 2018 to January 2019). Restricted cubic splines (RCS) were used to analyze the relation of NLR and all-causes 90-day transplant-free mortality in cirrhosis.

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Background: Chronic liver diseases (CLD), including cirrhosis and non-cirrhotic liver diseases, are globally widespread and create a serious disease burden. Platelet count is a clinically accessible and affordable prognostic indicator of liver disease. We investigated the relationship between platelet count and 90-day prognosis in patients with acute-on-chronic liver diseases (AoCLD).

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Hepatic encephalopathy is a severe complication, and its contribution to clinical adverse outcomes in patients with acute-on-chronic liver diseases from the East is unclear. We aimed to investigate the impact of hepatic encephalopathy on clinical characteristics and adverse outcomes in prospective and multicenter cohorts of patients with acute-on-chronic liver diseases. We conducted a cohort study of two multicenter prospective cohorts.

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Total bilirubin (TB) is a major prognosis predictor representing liver failure in patients with acute on chronic liver failure (ACLF). However, the cutoff value of TB for liver failure and whether the same cutoff could be applied in both cirrhotic and non-cirrhotic patients remain controversial. There is a need to obtain the quantitative correlation between TB and short-term mortality evidence-based methods, which is critical in establishing solid ACLF diagnostic criteria.

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Introduction: Spontaneous fungal ascites infection is a rare but devastating complication of cirrhosis. We aimed to analyse the clinical features, short-term mortality, and treatment of spontaneous fungal ascites infection in patients with cirrhosis.

Methods: We retrospectively studied ten patients with cirrhosis and spontaneous fungal ascites infections, and the clinical characteristics and outcomes were obtained.

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