p38-mediated FOXN3 phosphorylation modulates lung inflammation and injury through the NF-κB signaling pathway.

NF-κB activates the primary inflammatory response pathway responsible for methicillin-resistant Staphylococcus aureus (MRSA)-induced lung inflammation and injury. Here, we report that the Forkhead box transcription factor FOXN3 ameliorates MRSA-induced pulmonary inflammatory injury by inactivating NF-κB signaling. FOXN3 competes with IκBα for binding to heterogeneous ribonucleoprotein-U (hnRNPU), thereby blocking β-TrCP-mediated IκBα degradation and leading to NF-κB inactivation.

Extracellular vesicle-transmitted miR-671-5p alleviates lung inflammation and injury by regulating the AAK1/NF-κB axis.

Mesenchymal stem cells regulate remote intercellular signaling communication via their secreted extracellular vesicles. Here, we report that menstrual blood-derived stem cells alleviate acute lung inflammation and injury via their extracellular vesicle-transmitted miR-671-5p. Disruption of this abundantly expressed miR-671-5p dramatically reduced the ameliorative effect of extracellular vesicles released by menstrual blood-derived stem cells on lipopolysaccharide (LPS)-induced pulmonary inflammatory injury.

From prospecting to mining: A review of enabling technologies, LCAs, and LCCAs for improved construction and demolition waste management.

Knowledge gained from anthropogenic resource prospecting can shed light on the theoretical potential of secondary resources stored in anthropogenic systems. Among others, secondary resources accumulated in the built environment account for a big fraction of anthropogenic resources, indicating great potential for urban mining. However, realizing these opportunities and developing urban mining strategies will require a comprehensive understanding of the technical viability of urban mining technologies, and how their implementation will affect the technical, economic, and environmental performance of a construction and demolition waste (C&DW) management system.

[Data-driven study of complex socio-economic-natural ecosystems: Scales, processes and decision linkages].

The social-economic-natural system is a complex system for human survival and development, and the data-driven system research provides a new value-added orientation to enhance the cognition of the ecosystem. Under the new data context, the social-economic-natural complex system shows new features. The research object is gradually changing from a single element to a multi-factor coupling direction, which makes the data system more diversified, data sources more extensive, data expression more visualized.

Life cycle cost analysis of solar energy via environmental externality monetization.

Evaluating the embodied environmental impact of solar photovoltaic (PV) technology has been an important topic in addressing the sustainable development of renewable energy. While monetization of environmental externality is a remaining issue, which should be carried out in order to allow for an easy-to-understand comparison between direct economic and external cost. In this study, the environmental impact of solar PV power is monetized through conversion factors between midpoint and endpoint categories of life cycle analysis and the monetization weighting factor.

Review of construction and demolition waste management in China and USA.

It has been observed that the massive urbanization has boosted up infinite construction in the developed as well as developing countries. The construction and demolition waste has been correspondingly increased enormously which results in nasty and fatal impacts on urban sustainability and survival in the term of economic values and environmental safety. Considering construction and demolition waste management (CDWM) in the USA and China and its comparison has not been discussed, this study explores some research questions to fill such gaps: What are the existing CDWM policies and regulations in these two countries? What is the market mode for CDWM? What are the key challenges of CDWM? What are the CDWM contribution and limitations toward circular economy? What are the lessons that must be exemplary for the two economies through mutual learning? Our results show that the CD waste generation and its management are influenced by several factors including population, urbanization, gross domestic product (GDP), and CDWM regulatory measures.

Building Material Use and Associated Environmental Impacts in China 2000-2015.

A rapidly increasing use of building materials poses threats to resources and the environment. Using novel, localized life cycle inventories and building material intensity data, this study quantifies the resource use of building materials in mainland China and evaluates their embodied environmental impacts. Newly built floor area and related material consumption grew 11% per annum from 2000 to 2015, leveling off at the end of this period.