Publications by authors named "Beihua Shao"
Article Synopsis
- - The study investigates the presence and role of an intrinsic cholinergic system in the heart, which uses acetylcholine (ACh) to manage electrical conduction and its link to arrhythmias in humans and mice.
- - Researchers identified key components of this system, such as ACh receptors and transporters, showing that they significantly influence how electrical signals are conducted in heart cells.
- - Findings suggest that defects in this cholinergic system can lead to serious ventricular arrhythmias, highlighting new mechanisms for understanding heart rhythm disorders beyond traditional views.
Article Synopsis
- * The protein YTHDF2, which recognizes a specific chemical modification in mRNA called mA, plays a crucial role in regulating Cav1.2 expression and the onset of AF.
- * Knocking out YTHDF2 reduces AF risk in mice by increasing Cav1.2 levels independently of mA, ultimately affecting the heart's electrical activity and making YTHDF2 a potential target for AF treatment.
The sinoatrial node (SAN) is the origin of the electrical signals for rhythmic heartbeats in mammals. The spontaneous firing of SAN pacemaker cells (SANPCs) triggers cardiac contraction. 'Local Ca release' (LCR), a unique cellular activity, acts as the 'engine' of the spontaneous firing of SANPCs.
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