A retrospective cohort study of clinical characteristics and outcomes of type 2 diabetic patients with kidney disease.

Background: Type 2 diabetes mellitus (T2DM) with chronic kidney disease (CKD) poses a serious health threat and becomes a new challenge. T2DM patients with CKD fall into three categories, diabetic nephropathy (DN), non-diabetic kidney disease (NDKD), and diabetic nephropathy plus non-diabetic kidney disease (DN + NDKD), according to kidney biopsy. The purpose of our study was to compare the clinical characteristics and kidney outcomes of DN, NDKD, and DN + NDKD patients.

Glutamine Metabolism Promotes Renal Fibrosis through Regulation of Mitochondrial Energy Generation and Mitochondrial Fission.

Fibroblast activation and proliferation is an essential phase in the progression of renal fibrosis. Despite the recognized significance of glutamine metabolism in cellular growth and proliferation, its precise pathophysiological relevance in renal fibrosis remains uncertain. Therefore, this study aims to investigate the involvement of glutamine metabolism in fibroblast activation and its possible mechanism.

[Construction methods of urban ecological corridor for birds: A review].

The ecological corridors considering bird movement characteristics and habitat requirements would mitigate species extinction caused by habitat loss or habitat fragmentation and facilitate species gene dispersal and exchange. These functions may in turn benefit urban residents' physical and mental health as well as appreciation of real estates. Nonetheless, main ecological corridor construction methods developed by foreign scholars have not internally considered the movement and habitat characteristics of birds, while corridor research for birds by domestic scholars have focused on explorations of foreign technical methods yet lacked enough knowledge on studied birds' characteristics.

Efficacy and safety of combination therapy with sodium-glucose cotransporter 2 inhibitors and renin-angiotensin system blockers in patients with type 2 diabetes: a systematic review and meta-analysis.

Background: This study was designed to evaluate the efficiency and safety of combination therapy with sodium-glucose cotransporter 2 (SGLT2) inhibitors and renin-angiotensin system blockers such as angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) in patients with type 2 diabetes mellitus (T2DM).

Methods: We searched the PubMed, Embase, Web of Science and Cochrane Library databases from their inception to May 2020. Two authors independently performed study selection, risk-of-bias assessment and data extraction.