AKH/AKHR signalling system induced antioxidant response mediated by entomopathogenic fungi in Nilaparvata lugens (Stål).

The brown planthopper Nilaparvata lugens is one of the most economically important rice crop pests in Asia. Entomopathogenic fungi (EPF) have been developed as a biological control of N. lugens.

Carvacrol acetate activated Nrf2 modulates mitophagy for the treatment of neurocyte oxidative stress induced by chlorpyrifos.

This study explored the protective effect and potential mechanism of carvacrol acetate (CAA) on the oxidation of chlorpyrifos (CPF). A model of oxidative stimulus damage was established in Sprague-Dawley rats by subcutaneous injection of the CPF poison. PC12 cells were used to construct an oxidative injury model using CPF, and the protective effects and mechanism of action of CAA against CPF-induced oxidative damage were explored in vitro.

Transcriptomics integrated with metabolomics reveals the effect of benzo[a]pyrene exposure on acute lung injury.

Benzo[a]pyrene (BaP), a major harmful component in PM2.5, is widely present in automobile emissions and atmospheric pollution. BaP exposure directly targets the lungs, often resulting in acute lung injury (ALI).

Engineering a fluorescent probe for the visual and wearable detection of NH in foods, environment samples and biological imaging.

Hydrazine (NH), as an important chemical raw material widely used in many fields, caused serious harm to human, food and environment. Therefore, a smart fluorescent probe TPC-NH with intramolecular charge transfer (ICT) process was fabricated for colorimetric and fluorescent differentiating of NH in many samples. When TPC-NH met NH, blue emission at 451 nm was obviously observed attributed to the interruption of ICT process, resulting in the formation of the hydrazone structure.

Association between hypothyroidism and metabolic syndrome in Qinghai, China.

Objective: To investigate the epidemiological characteristics of hypothyroidism in Qinghai Province, analyze its related influencing factors, establish the normal reference range of thyroid function, and explore the relationship between thyroid hormone (THs), thyroid stimulating hormone (TSH) and metabolic syndrome (MS) in Qinghai population within the normal range, so as to provide some scientific basis for the prevention and treatment of hypothyroidism in Qinghai Province.

Methods: A total of 2790 residents aged 18 and over from Qinghai were selected through stratified cluster random sampling. Data were collected via questionnaires, physical examinations, and laboratory tests.

Research note: Changes in chicken egg yolk metabolome during its spray drying and storage.

The differences in metabolites between fresh egg yolk (FEY), spray-dried egg yolk powder (SEY), and stored egg yolk powder (S-SEY) were quantitatively compared through metabolomic analysis. Total of 1004 metabolites were identified in the three groups of egg yolk samples. In pairwise group analysis, 242 differential metabolites were identified in FEY and SEY, 311 differential metabolites were identified in FEY and S-SEY, and 157 differential metabolites were identified in SEY and S-SEY.

Integrating external stressors in supervised machine learning algorithm achieves high accuracy to predict multi-species biological integrity index of aquaculture wastewater.

Monitoring and predicting the environmental impact of wastewater is essential for sustainable aquaculture. The environmental DNA metabarcoding-integrated supervised machine learning (SML) algorithm is an alternative method for ecological quality assessment and prediction. However, the ecological integrity of aquaculture wastewater and available effective input features for prediction remain unclear.

High-Efficiency Clustering Routing Protocol in AUV-Assisted Underwater Sensor Networks.

Currently, underwater sensor networks are extensively applied for environmental monitoring, disaster prediction, etc. Nevertheless, owing to the complicacy of the underwater environment, the limited energy of underwater sensor nodes, and the high latency of hydroacoustic channels, the energy-efficient operation of underwater sensor networks has become an important challenge. In this paper, a high-efficiency clustering routing protocol in AUV-assisted underwater sensor networks (HECRA) is proposed to address the energy limitations and low data transmission reliability in underwater sensor networks.

Case Series Analysis of Diagnosis and Treatment of Gastrointestinal Metastasis in Lung Cancer Patients.

Objective: This study was designed to investigate the clinical, pathological, endoscopic, and imaging characteristics of gastrointestinal metastasis in patients with lung cancer.

Methods: The clinical data of 20 patients with primary lung cancer with gastrointestinal metastasis.

Results: This study included sixteen men and four women, ranging in age from 31 to 75 years.

Regulation of colon injury and improvement of exercise performance in exhausted running mice by CQZC02.

In this study, strenuous forced exercise caused intestinal damage and reduced the exercise capacity of mice. However, the antioxidant and anti-inflammatory properties of CQZC02 (LPCQZC02) were found to improve both the intestinal barrier and exercise function in mice. The effectiveness of LPCQZC02 was confirmed through various methods, including kit detection, pathological observation, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and intestinal flora analysis.

Unusual Triple-State Switching of Thermally Induced Birefringence in a Two-Dimensional Perovskite Ferroelectric.

Birefringent crystals hold a significant position in optical and optoelectronic fields due to their capability to control polarized light. Despite various chemical strategies devoted to designing birefringent crystals, it remains a challenge to switch and manipulate birefringence under physical stimuli. Here we present an unusual triple-state switching of birefringence in a 2D perovskite ferroelectric, (-methylcyclohexylammonium)PbCl (), which exhibits two reversible phase transitions at 361 and 373 K.

ALCAT1-Mediated Pathological Cardiolipin Remodeling and PLSCR3-Mediated Cardiolipin Transferring Contribute to LPS-Induced Myocardial Injury.

Cardiolipin (CL), a critical phospholipid situated within the mitochondrial membrane, plays a significant role in modulating intramitochondrial processes, especially in the context of certain cardiac pathologies; however, the exact effects of alterations in cardiolipin on septic cardiomyopathy (SCM) are still debated and the underlying mechanisms remain incompletely understood. This study highlights a notable increase in the expressions of ALCAT1 and PLSCR3 during the advanced stage of lipopolysaccharide (LPS)-induced SCM. This up-regulation potential contribution to mitochondrial dysfunction and cellular apoptosis-as indicated by the augmented oxidative stress and cytochrome c (Cytc) release-coupled with reduced mitophagy, decreased levels of the antiapoptotic protein B-cell lymphoma-2 (Bcl-2) and lowered cell viability.

Enhanced health risk of soil heavy metal exposure following an extreme rainstorm under climate change.

Widespread concerns raised in changes in the health risk of soil heavy metals exposure due to extreme rainstorm under climate change. However, the impacts of extreme rainstorm on human exposure risk and the underlying mechanisms are still unclear. In this study, soil properties, speciation distribution and bioaccessibility of Ni, Cu, Zn, Cd and Pb in soil samples, which were collected before and after extreme rainstorm, were measured, subsequently the soil oral exposure risk of heavy metals was assessed based on bioaccessibility.

Dynamic trends of ischemic heart disease mortality attributable to high low-density lipoprotein cholesterol: a joinpoint analysis and age-period-cohort analysis with predictions.

Aims: The purpose of this study was to analyze the dynamic trends of ischemic heart disease (IHD) mortality attributable to high low-density lipoprotein cholesterol (LDL-C).

Methods: Data on IHD mortality attributable to high LDL-C from 1990 to 2021 were extracted from the global disease burden database. Joinpoint software was used to estimate the average annual percentage change (AAPC) in the age-standardized mortality rate (ASMR).

Targeting Liver Epsins Ameliorates Dyslipidemia in Atherosclerosis.

Rationale: Low density cholesterol receptor (LDLR) in the liver is critical for the clearance of low-density lipoprotein cholesterol (LDL-C) in the blood. In atherogenic conditions, proprotein convertase subtilisin/kexin 9 (PCSK9) secreted by the liver, in a nonenzymatic fashion, binds to LDLR on the surface of hepatocytes, preventing its recycling and enhancing its degradation in lysosomes, resulting in reduced LDL-C clearance. Our recent studies demonstrate that epsins, a family of ubiquitin-binding endocytic adaptors, are critical regulators of atherogenicity.