Publications by authors named "Beibei Shen"

Article Synopsis
  • - Over 60% of epilepsy patients face cognitive issues like learning and memory problems, but treatments currently only address seizure symptoms without targeting cognitive impairment.
  • - Deep brain stimulation (DBS) has been established as a safe method for treating tough epilepsy cases and shows promise not just for controlling seizures but also for enhancing cognitive functions.
  • - This review explores the effects of DBS on cognitive impairment in epilepsy, including its mechanisms, various treatment targets, and future clinical applications, providing valuable insights for treating patients with both epilepsy and cognitive dysfunction.
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Flixweed () is a weed that seriously affects wheat fields in China. Over the past 20 years, it has evolved resistance to the herbicide tribenuron-methyl. In the present study, a resistant population with a Pro-197-Thr mutation of acetolactate synthetase (ALS) was found to have a resistance index of 457.

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Background: In the progestin-primed ovarian stimulation protocol, the oral administration of medroxyprogesterone acetate has been observed to effectively inhibit the LH surge during ovarian stimulation in patients experiencing infertility. Nevertheless, the use of utilizing medroxyprogesterone acetate during ovarian stimulation can result in more pronounced pituitary suppression, potentially necessitating increased doses of gonadotropins and extended treatment durations. Therefore, it is necessary to determine the optimal dose of medroxyprogesterone acetate, aiming to use relatively lower concentrations of medroxyprogesterone acetate to effectively and safely suppress early LH surges.

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Background: This study aims to analyze the risk factors associated with prolonged mechanical ventilation (PMV) in patients following surgical treatment for acute type A aortic dissection (ATAAD). The objectives include constructing a predictive model for risk assessment and validating its predictive efficacy.

Methods: A total of 452 patients diagnosed with ATAAD and undergoing surgical procedures at a tertiary hospital in Nanjing between January 2021 and April 2023 were selected using a convenience sampling method.

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Land use/land cover (LULC) change and climate change are interconnected factors that affect the ecological environment. However, there is a lack of quantification of the impacts of LULC change and climate change on landscape ecological risk under different shared socioeconomic pathways and representative concentration pathways (SSP-RCP) on the Mongolian Plateau (MP). To fill this knowledge gap and understand the current and future challenges facing the MP's land ecological system, we conducted an evaluation and prediction of the effects of LULC change and climate change on landscape ecological risk using the landscape loss index model and random forest method, considering eight SSP-RCP coupling scenarios.

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Japanese brome (Bromus japonicus) has become one of the main weeds in wheat fields in Hebei province of China and causes a large decrease of wheat production. A total of 44 putative resistant and 2 susceptible Japanese brome populations were collected in the 2021/2022 crop season from Hebei province of China to determine resistance levels to flucarbazone‑sodium and to investigate the diversity of acetolactate synthase (ALS) mutations, as well as to confirm the cross-and multiple-resistance levels to ALS and EPSPS (5-enolpyruvate shikimate-3-phosphate synthetase) inhibitors. Whole plant bioassay results showed that 15 out of 44 populations tested or 34% were resistant to flucarbazone‑sodium.

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The Eurasian steppe is the largest temperate grassland in the world. The grassland of the Mongolian Plateau (MP) represents an important part of the Eurasian steppe with high climatic sensitivity. Gross primary productivity (GPP) is a key indicator of the grassland's production, status and dynamic on the MP.

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The sensitivity of grassland above- (AGB, gC m) and below-ground biomass (BGB, gC m) to climate has been shown to be significant on the Tibetan Plateau, however, the spatial patterns and sensitivity of biomass with altitudinal change needs to be quantitated. In this study, large data sets of AGB and BGB during the peak growth season, and the corresponding geographical and climate conditions in the grasslands of the Tibetan Plateau between 2001 and 2020 were analyzed, and modelled using a Cubist regression trees algorithm. The mean values for AGB and BGB were 61.

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Purpose: We aim to understand the knowledge of and attitudes toward pregnancy issues among women with epilepsy (WWE) and their caregivers and analyze the answers from the questionnaire to expose topics that require educational activities; thus, WWE experiences pregnancy better.

Methods: WWE at their childbearing age and/or their caregivers who entered the Fourth Affiliated Hospital of Zhejiang University for treatment of their condition were invited to fill out a questionnaire between March 1 and November 31, 2022.

Results: A combined total of 205 WWE and 142 caregivers completed the questionnaires.

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Objective: Children with self-limited epilepsy characterized by centrotemporal spikes (SeLECTS) exhibit cognitive deficits in memory during the active phase, but there is currently a lack of studies and techniques to assess their memory development after well-controlled seizures. In this study, we employed eye-tracking techniques to investigate visual memory and its association with clinical factors and global intellectual ability, aiming to identify potential risk factors by examining encoding and recognition processes.

Methods: A total of 26 recruited patients diagnosed with SeLECTS who had been seizure-free for at least 2 years, along with 24 control subjects, underwent Wechsler cognitive assessment and an eye-movement-based memory task while video-electroencephalographic (EEG) data were recorded.

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Descurainia sophia (flixweed) is a troublesome weed in winter wheat fields in North China. Resistant D. sophia populations with different acetolactate synthetase (ALS) mutations have been reported in recent years.

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Article Synopsis
  • * A study involving 232 cardiac surgery patients identified postoperative lactate levels, maximum temperature, and cardiopulmonary bypass time as significant predictors of POD, with a 12.1% incidence rate.
  • * A predictive model was developed from these factors, showing strong accuracy (C-statistic of 0.852), which could help in identifying patients at risk for POD and guide preventive strategies.
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High-accuracy simulation of gross primary productivity (GPP) is crucial for the monitoring and evaluation of the ecosystem services and the adaptive management of grassland. The light use efficiency (LUE) model is one of the most widely-used methods to simulate GPP, given its simple structure and low input requirements. Current LUE models are less applicable to grasslands than other vegetation types and have lower overall estimation accuracy in arid and semi-arid regions.

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Article Synopsis
  • - The study focuses on using the Ocean and Land Color Imager (OLCI) on Sentinel-3 to accurately estimate grassland leaf area index (LAI), fractional vegetation cover (FVC), and aboveground biomass (AGB), comparing its performance to MODIS data.
  • - Utilizing a Bayesian spatial model (INLA-SPDE) to account for spatial correlations enhances prediction accuracy, with S3 OLCI displaying superior results over MODIS—reducing errors in LAI, FVC, and AGB predictions significantly.
  • - The analysis highlights the effectiveness of red edge bands in improving estimation accuracy, as well as the INLA-SPDE model outperforming other techniques like random forests in terms of bias and alignment with
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Article Synopsis
  • - The study investigates the impact of TMPRSS2-ERG gene fusions in prostate cancer, highlighting that deletion-derived fusions are linked to more aggressive forms compared to insertional fusions.
  • - Analysis of prostate cancer transcriptome data identified the loss of the FAM3B gene as a key factor correlated with poor prognosis, influencing not only TMPRSS2-ERG fusion cancers but also fusion-negative cases.
  • - FAM3B's loss disrupts a regulatory feedback loop with the androgen receptor, leading to increased androgen receptor activity and accelerating prostate cancer progression, indicating its potential as a new target for treatment strategies.
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Livestock-grassland interactions are among the most important relationships in grazed grassland ecosystems, where herbivores play a crucial role in plant community and ecosystem functions. However, previous studies primarily have focused on the responses of grasslands to grazing, with few focussing on the effects of livestock behaviour that in turn would influence livestock intake and primary and secondary productivity. Through a 2-year grazing intensity experiment with cattle in Eurasian steppe ecosystem, global positioning system (GPS) collars were used to monitor animal movements, where animal locations were recorded at 10-min intervals during the growing season.

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Kinesin-1 is an ATP-driven, two-headed motor protein that transports intracellular cargoes (loads) along microtubules. The movement of kinesin-1 has generally been modeled according to its correlation with ATP cleavage (forward movement), synthesis (backward movement), or unproductive cleavage (futile consumption). Based on recent experimental observations, we formulate a mechanochemical model for this movement in which the forward/backward/futile cycle can be realized through multiple biochemical pathways.

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The Eurasian steppe is the largest steppe region in the world and is an important part of the global grassland ecosystem. The eastern Eurasian steppe has favorable hydrothermal conditions and has the highest productivity and the richest biodiversity. Located in the arid and semi-arid region, the eastern Eurasian steppe has experienced large-scale grassland degradation due to dramatic climate change and intensive human activities during the past 20 years.

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Objective: Mucin 1 (MUC1/EMA) and sialyl Lewis X (sLe) indicate polarity reversal in invasive micropapillary carcinoma (IMPC). The purpose of this study was to evaluate the expression of MUC1/EMA and sLe and to assess their diagnostic and prognostic value in patients with IMPC.

Methods: The expression of sLe and MUC1/EMA in 100 patients with IMPC and a control group of 89 patients with invasive ductal carcinoma not otherwise specified (IDC-NOS) were analyzed with IHC.

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Release and transport of contaminants in watersheds can have adverse effects on aquatic organisms and human health. Little attention, however, has been paid to chemical contamination of aquatic environments in arid regions by persistent organic pollutants. We analyzed the concentrations and distributions of organochlorine pesticides (OCPs) and polycyclic aromatic hydrocarbons (PAHs) in waters of the Ili-Balkhash Basin, in arid central Asia.

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Background: Anxiety is common during pregnancy. The 7-item Generalized Anxiety Disorder scale (GAD-7) is a self-rating scale for detecting anxiety and has been validated in various populations, but it has not been validated in pregnant Chinese women. The objective of this study was to validate the GAD-7 as a screening tool to detect anxiety during pregnancy among Chinese women.

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Background: Primary signet ring cell carcinoma (SRCC) of the breast is a rare entity, and only a few case reports of the pure SRCC cases could be found in English literatures. We summarized the clinicopathological characteristics of a relatively large cohort of pure breast SRCCs for the first time.

Methods: We reviewed the medical records of 23 cases of pure breast SRCC with a median follow-up time of 70 months.

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To explore impact of Ataxia telangiectasia mutated (ATM) kinase on immunoreactions in lymphocyte-predominant breast cancer (LPBC), particularly its role in triple negative breast cancer (TNBC), 194 cases of LPBC were identified with pertinent clinical information retrieved. The expressions of ATM, activated ATM (P-ATM), Fas ligand (FASL), tumor necrosis factor-related apoptosis-induced ligand (TRAIL), major histocompatibility complex class I chain-related protein A (MICA), CD8, and Forkhead box P3 (FOXP3) were assessed by immunohistochemically. We found that ATM expressed on tumor cells was correlated with upregulated expression of P-ATM and MICA (P < 0.

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Article Synopsis
  • Triple negative breast cancer (TNBC) is a tough-to-treat cancer type, and the impact of Interleukin 17 (IL-17) on its progression is not well understood yet.
  • Researchers used immunohistochemistry to study IL-17+ cells in TNBC-NST, finding a higher presence of these cells compared to TNBC-MC, along with significant links to cancer prognosis.
  • The study suggests that IL-17 might promote tumor development through mechanisms related to blood vessel formation, and it could become a target for new treatments in TNBC-NST.
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