Exploring the feasibility of home-delivered capsule endoscopy with 5G support: innovations and carbon footprint insights.

Introduction: Colorectal cancer (CRC) poses a significant global health threat, necessitating early detection. Traditional diagnostic tools like optical colonoscopy have limitations prompting our '5G-SUCCEEDS' initiative to explore a novel approach involving remote colon capsule endoscopy (CCE).

Methods: This prospective feasibility study was conducted at a single hospital in England.

USP5 promotes tumor progression by stabilizing SLUG in bladder cancer.

Bladder cancer ranks as the second most prevalent urology malignancy globally. Invasive metastasis is a significant contributor to mortality among patients with bladder cancer, yet the underlying mechanisms remain elusive. Deubiquitinases are pivotal in carcinogenesis, with USP5 implicated in the malignant progression of hepatocellular carcinoma, colorectal cancer and non-small cell lung cancer.

Probabilistic human health risk assessment of PCDD/Fs near municipal solid-waste incinerator using Monte Carlo analysis coupled with triangular fuzzy numbers.

PCDD/Fs are dioxins produced by waste incineration and pose risks to human health. We aimed to detail the health risks of airborne and soil PCDD/Fs near a municipal solid-waste incinerator (MSWI) for the surrounding population and develop a new model that improves upon existing methods. Thus, we conducted field sampling and then investigated a MSWI in the Pearl River Delta (2016-2018).

Health risk assessment of trace metal(loid)s in agricultural soil using an integrated model combining soil-related and plants-accumulation exposures: A case study on Hainan Island, South China.

Traditional health risk assessment of trace metal(loid)s (TMs) in agricultural soil exclusively considers direct soil-related exposure and may underestimate the health risks they pose. In this study, the health risks of TMs were evaluated using an integrated model that combined soil-related and plant-accumulating exposures. A detailed investigation of common TMs (Cr, Pb, Cd, As, and Hg) coupled with probability risk analysis based on a Monte Carlo simulation was conducted on Hainan Island.

Structural and functional biomimetics of [Fe]-hydrogenase featuring a mono-, di- or tetrasubstituted pyridine ligand with a -C, N, and S ligation.

The combined structural and functional modeling study of [Fe]-Hase has remained a great challenge, to date. Now, we report a series of new structural and functional [Fe]-Hase models (1-6) that contain a mono-, di- or tetrasubstituted pyridine ligand with a biomimetic -C, N, and S ligation. While models 1-3, 5 and 6 are conveniently prepared by a novel flexible pyridine ligand (FPL)-based method, model 4 is prepared simply by an intramolecular CO replacement reaction of model 3.

Biomimetic models of [Fe]-hydrogenase featuring a 2-acylphenylthiomethyl-6-R-pyridine (R = H or OMe) ligand.

Despite a variety of [Fe]-Hase models prepared so far, the structural and functional modeling study of the enzyme has remained a great challenge. Now, we report a new type of flexible pyridine ligand (FPL)-based synthetic method by which two novel [Fe]-Hase models have been prepared. Notably, the two models contain not only a biomimetic -acyl C, pyridyl N, thioether S coordination mode but also possess the enzyme-like H/D activation functions.

Policy Implementation Inconsistency and Emission Leakage: Evidence from The Closure of Polluting Firms.

Public policies often fail to address the unintended behavior of regulated firms and are therefore inconsistent in their implementation, resulting in ineffectiveness. In the process of environmental policy, policy implementation inconsistencies also exist, which is known as emission leakage. Existing studies on the topic focus more on spatial dimension and less attention to time dimension.

Dynamic responses of soil enzymes at key growth stages in rice after the in situ remediation of paddy soil contaminated with cadmium and arsenic.

The practical application of in situ remediation techniques requires an understanding of the dynamic changes in soil enzyme activity as indicators of soil fertility and health. Experiments were carried out in paddy soils co-contaminated with cadmium (Cd) and arsenic (As) at low (L) and high (H) levels. A calcium and iron (CaFe)-based amendment (limestone + iron powder + silicon fertilizer + calcium‑magnesium-phosphate fertilizer) was applied to the soil at concentrations of 0, 450, and 900 g·m (labeled CK, T1, and T2, respectively), and sampling was conducted at the tillering (TS), booting (BS), filling (FS), and mature (MS) stages.

Prevalence and diagnostic agreement of sarcopenic obesity with different definitions among Chinese community-dwelling older adults.

Objective: this retrospective study aims to compare the prevalence and diagnostic agreement of sarcopenic obesity (SO) using different obesity diagnostic methods among Chinese community-dwelling older adults.

Methods: SO was diagnosed with sarcopenia and obesity diagnostic methods. Sarcopenia was defined using the Asian Working Group for Sarcopenia criteria 2019 (AWGS2019).

Brown Adipose Tissue Activation Is Involved in Atherosclerosis of ApoE Mice Induced by Chronic Intermittent Hypoxia.

Obstructive sleep apnea is an atherogenesis factor of which chronic intermittent hypoxia is a prominent feature. Chronic intermittent hypoxia (CIH) exposure can sufficiently activate the sympathetic system, which acts on the β3 adrenergic receptors of brown adipose tissue (BAT). However, the activity of BAT and its function in CIH-induced atherosclerosis have not been fully elucidated.

Early combined rehabilitation intervention to improve the short-term prognosis of premature infants.

Background: To explore the clinical effect of early combined rehabilitation intervention on premature infants in the neonatal intensive care unit (NICU).

Methods: Premature infants with gestational ages less than 32 weeks or birth weights less than 1500 g were included in the present study.The participants were divided into the intervention group and control group.

Fe-S Catalyst Generated In Situ from Fe(III)- and S-Promoted Aerobic Oxidation of Terminal Alkenes.

An iron-sulfur complex formed by the simple mixture of FeCl with S generated in situ from KS is developed and applied to selective aerobic oxidation of terminal alkenes. The reaction was carried out under an atmosphere of O (balloon) and could proceed on a gram scale, expanding the application of S in organic synthesis. This study also encourages us to explore the application of an Fe-S catalyst in organic reactions.

New insights into BMP9 signaling in liver diseases.

Bone morphogenetic protein 9 (BMP9) is a recently discovered cytokine mainly secreted by the liver and is a member of the transforming growth factor β (TGF-β) superfamily. In recent years, an increasing number of studies have shown that BMP9 is associated with liver diseases, including nonalcoholic fatty liver disease (NAFLD), liver fibrosis and hepatocellular carcinoma (HCC), and BMP9 signaling may play dual roles in liver diseases. In this review, we mainly summarized and discussed the roles and potential mechanisms of BMP9 signaling in NAFLD, liver fibrosis and HCC.

[Effects of resistance exercise on pyroptosis-related proteins in hippocampus of insulin resistant mice].

To investigate the changes of pyroptosis-related proteins in the hippocampus of insulin-resistant mice and the regulation of resistance training on pyroptosis-related proteins. Six-week-old male C57BL/6J mice were randomly divided into control group (C, =12) and high-fat diet group (HFD, =26) for normal or high-fat diet for 12 weeks. Subsequently, according to the results of glucose tolerance test (GTT) and insulin tolerance test (ITT), the rats fed with high-fat diet were divided into insulin resistance group (IR, =10) and resistance exercise group (RT, =10) as well as to maintain high-fat diet.

Centromere protein U enhances the progression of bladder cancer by promoting mitochondrial ribosomal protein s28 expression.

Bladder cancer is one of the most common types of cancer. Most gene mutations related to bladder cancer are dominantly acquired gene mutations and are not inherited. Previous comparative transcriptome analysis of urinary bladder cancer and control samples has revealed a set of genes that may play a role in tumor progression.

Oleic Acid (OA), A Potential Dual Contrast Agent for Postmortem MR Angiography (PMMRA): A Pilot Study.

Choosing proper perfusates as contrast agents is an important aspect for postmortem magnetic resonance angiography (PMMRA). However, in this emerging field, the number of suitable kinds of liquid is still very limited. The objective of this research is to compare MR images of oleic acid (OA) with paraffin oil (PO) in vitro and in ex situ animal hearts, in order to evaluate the feasibility to use OA as a novel contrast agent for PMMRA.

Heterodinuclear nickel(ii)-iron(ii) azadithiolates as structural and functional models for the active site of [NiFe]-hydrogenases.

To develop the biomimetic chemistry of [NiFe]-Hases, the first azadithiolato-bridged NiFe model complexes [CpNi{(μ-SCH)NR}Fe(CO)(diphos)]BF (5, R = Ph, diphos = dppv; 6, 4-ClCH, dppv; 7, 4-MeCH, dppv; 8, COCHPh, dppe; 9, H, dppe) have been synthesized well-designed synthetic routes. Thus, treatment of RN[CHS(O)CMe] with -BuONa followed by reaction of the resulting intermediates RN(CHSNa) with (dppv)Fe(CO)Cl or (dppe)Fe(CO)Cl gave the N-substituted azadithiolato-chelated Fe complexes [RN(CHS)]Fe(CO)(diphos) (1, R = Ph, diphos = dppv; 2, 4-ClCH, dppv; 3, 4-MeCH, dppv; 4, COCHPh, dppe). Further treatment of 1-4 with nickelocene in the presence of HBF·EtO afforded the corresponding N-substituted azadithiolato-bridged NiFe model complexes 5-8, while treatment of 8 with HBF·EtO resulted in formation of the parent azadithiolato-bridged model complex 9.

[Aerobic exercise reduces the expression of pyroptosis-related proteins and inflammatory factors in hippocampus of mice with insulin resistance].

The aim of the present study was to observe the expression of pyroptosis- and inflammation-related proteins in the hippocampus of mice with insulin resistance (IR) after aerobic exercise, and to explore the possible mechanism of exercise to improve IR. C57BL/6J male mice of 6 weeks old were randomly fed with normal diet (n = 12) and high-fat diet (HFD) (n = 26) for 12 weeks respectively. Glucose tolerance test (GTT) and insulin tolerance test (ITT) were performed to determine whether IR occurred in HFD mice.

Comparison of Three Screening Methods for Sarcopenia in Community-Dwelling Older Persons.

Objective: The 2019 Asian Working Group on Sarcopenia in Older People (AWGS 2019) recommends using either calf circumference or the strength, assistance in walking, rising from a chair, climbing stairs, and falls (SARC-F) or SARC-F combined with calf circumference (SARC-CalF) questionnaires for sarcopenia screening. The aim of this study was to compare the ability and applicability of calf circumference, SARC-F, and SARC-CalF for screening sarcopenia among community-dwelling older adults.

Design: Cross-sectional study.

Folium Sennae and emodin reverse airway smooth muscle contraction.

The objective of this project was to find a bronchodilatory compound from herbs and clarify the mechanism. We found that the ethanol extract of Folium Sennae (EEFS) can relax airway smooth muscle (ASM). EEFS inhibited ASM contraction, induced by acetylcholine, in mouse tracheal rings and lung slices.

Pharyngeal Ectopic Thymus: A Case Report.

Pharyngeal ectopic thymus is a rare cause of pharyngeal masses and is rarely considered in the differential diagnosis of neck and head masses in children. In this paper, the case of an infant with a pharyngeal ectopic thymus is presented and our intraoral surgical approach in the patient's treatment is described.

Author Correction: Increased circulating β2-adrenergic receptor autoantibodies are associated with smoking-related emphysema.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

The Molecular Mechanisms of Excessive Hippocampal Endoplasmic Reticulum Stress Depressing Cognition-related Proteins Expression and the Regulatory Effects of Nrf2.

Studies have shown that obesity-induced hyperglycemia and hyperlipidemia could cause increased hippocampal endoplasmic reticulum (ER) stress and impaired cognition-related proteins expression, resulting in learning and memory impairment. Meanwhile, aerobic exercise could activate hippocampal nuclear factor erythroid 2-related factor 2 (Nrf2) reducing ER stress. This study investigated the underlying molecular mechanisms of this effect.