Publications by authors named "Bei-Lei Chen"
Objective: On May 2, 2017, an outbreak of unexplained fever with rashes was reported in Lu'an, China. In this study, we aimed to identify the possible pathogens, epidemiological characteristics, and risk factors of this outbreak.
Methods: We conducted descriptive field epidemiological studies.
Article Synopsis
- Epithelial-specific ETS-1 (ESE1) is a transcription factor linked to inflammation and is found in many tissues, but its role after cerebral ischemia/reperfusion is not fully understood.
- Research using adult rats and PC12 cells demonstrated that ESE1 expression increases following ischemia, correlating with increased neuronal apoptosis markers like phosphorylated p65 and active caspase-3.
- Knocking down ESE1 in cell models improved cell survival under hypoxic conditions, suggesting that ESE1 could contribute to neuronal death during ischemic injury via the nuclear factor-κB signaling pathway.
Rationale: Pyoderma gangrenosum (PG) is a rare postoperative complication of enterostomy, mostly developing from dermatitis, which may have serious consequence.
Patient Concerns: A patient with lower rectal cancer receiving low anterior resection (LAR) and protective ileostomy was initially diagnosed with dermatitis, which very quickly developed to PG, though no medical or familial history was found.
Diagnosis: We diagnosed the patient with peristoaml dermatitis starting from a tiny skin ulceration, but corrected the diagnosis to PG because of the rapid development and severe consequences.
Background And Purpose: Few reports concerned on recombinant tissue plasminogen activator (rt-PA) treatment in stroke patients with decreased consciousness. This study assesses the efficacy and safety of intravenous rt-PA administration within 4.5 h in stroke patients with decreased consciousness.
View Article and Find Full Text PDF[Analysis of 994(G--> T) mutation in the plasma platelet-activating factor acetylhydrolase gene in the patients with cerebral infarction].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
August 2005
Objective: To investigate the relationship between plasma platelet-activating factor acetylhydrolase (PAF-AH) gene 994(G--> T) mutation in exon 9 and the patients with cerebral infarction in Chinese Hans.
Methods: The authors conducted a case-control study including 108 patients in three groups (atherosclerotic cerebral infarction group, lacunar infarction group and cerebral embolism group) and 215 normal subjects as controls. Genomic DNA was analyzed for the mutant allele by a specific polymerase chain reaction.