Bibliometrics analysis based on the Web of Science: Current trends and perspective of gastric organoid during 2010-2023.

Background: Three-dimensional organoid culture systems have been established as a robust tool for elucidating mechanisms and performing drug efficacy testing. The use of gastric organoid models holds significant promise for advancing personalized medicine research. However, a comprehensive bibliometric review of this bur-geoning field has not yet been published.

Research on Sustainable Development of Competitive Sports in China Based on PSR and DEA Model.

From the 2008 Beijing Olympic Games to the 2022 Beijing Winter Olympics, the sustainable development of competitive sports has become more and more popular in China. Therefore, for the sustainable development of China's competitive sports, first, the logical relationship of "pressure-state-response" is adopted to select the index system, covering the elements of the economy, society, policy, and so on. Principal component analysis and entropy weight method are used to construct the comprehensive evaluation model of the sustainable development of competitive sports.

One-stage surgical correction of congenital tracheal stenosis complicated with congenital heart disease in infants and young children.

Objectives: Although the outcome of surgical treatment of congenital tracheal stenosis (CTS) has improved, surgical intervention for these patients, especially for those with associated congenital heart disease (CHD) remains challenging. In this report, we summarized our experience with these defects.

Methods: Clinical data were collected for children undergoing tracheoplasty and CHD surgery from January 2001 to March 2013.

A pharmacodynamic simulation to evaluate tigecycline in treatment of nosocomial pneumonia caused by multidrug-resistant Acinetobacter baumannii.

The shortage of effective antibiotics against multidrug-resistant Acinetobacter baumannii (MDR-Ab) has posed great threat to the public health. But the advent of tigecycline gives us new hope. The goal of our research was to assess the clinical efficacy of tigecycline at different doses by using a pharmacokinetic/pharmacodynamic (PK/PD) model which can incorporate pharmacokinetic data of tigecycline from patients with pneumonia and MICs of MDR-Ab from a tertiary hospital.

Determination of thalidomide concentration in human plasma by liquid chromatography-tandem mass spectrometry.

A rapid, sensitive and specific analytical method based on high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed for the determination of thalidomide concentration in human plasma. The analyte and internal standard were extracted by liquid-liquid extraction with ether-dichloromethane (3:2, v/v) and separated on a TC-C(18) column using methanol-10 mM ammonium acetate-formic acid (60:40:0.04, v/v/v) as the mobile phase at a flow rate of 0.

Treatment of community-acquired pneumonia with moxifloxacin: a meta-analysis of randomized controlled trials.

Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality throughout the world. To investigate whether moxifloxacin monotherapy is associated with better clinical outcomes than other antibiotics recommended for CAP among adults with mild-to-moderate or severe CAP, we performed a meta-analysis. MEDLINE, EMBASE, Web of Science, and the Cochrane Library were searched for randomized control trials (RCTs).

The dual role of osteopontin in acetaminophen hepatotoxicity.

Aim: Osteopontin (OPN), a multifunctional protein, has been reported to be protoxicant in acetaminophen hepatotoxicity. In this study, the mechanisms underlying the detrimental role of OPN in acetaminophen toxicity were explored.

Methods: Male C57BL/6 (wild-type, WT) and OPN(-/-) mice were administered with acetaminophen (500 mg/kg, ip).

Single-dose pharmacokinetics and safety of iptakalim hydrochloride in Chinese healthy volunteers.

Objectives: To investigate the safety, pharmacokinetics and food effect of iptakalim in healthy adult Han Chinese volunteers.

Methods: Study 1 was a randomized open-label, Latin square designed, single-dose, three-period, self-control crossover study. Six men and six women received 5, 10 and 20 mg of iptakalim orally.

Effectiveness and safety of macrolides in cystic fibrosis patients: a meta-analysis and systematic review.

Objectives: To evaluate the efficacy and safety of macrolides in cystic fibrosis (CF).

Methods: Randomized controlled trials (RCTs) of macrolides for the treatment of CF published in PubMed, the Cochrane Library and Embase were searched. Application of inclusion and exclusion criteria, data extraction, and assessment of methodological quality were independently performed in duplicate.

In vitro activity of two old antibiotics against clinical isolates of methicillin-resistant Staphylococcus aureus.

The objective of this paper was to investigate the in vitro effects of fusidic acid combined with fosfomycin against methicillin-resistant Staphylococcus aureus (MRSA). In all, 196 MRSA strains isolated from three clinical specimens of human infections from hospitals in China were used in this study. The checkerboard method was used to determine whether combinations act synergistically against these strains.

Iron-Depletion prevents biofilm formation in Pseudomonas Aeruginosa through twitching mobility and quorum sensing.

Influence of iron-depletion on twitching motility and quorum sensing (QS) system in P. aeruginosa was evaluated. The results demonstrated iron-depletion can retard biofilm formation and increase the twitching motility and expression of QS-related genes, suggesting a potential interaction between twitching motility and QS system in P.

Effects of iron depletion on antimicrobial activities against planktonic and biofilm Pseudomonas aeruginosa.

Objectives: Iron plays an important role in the development of Pseudomonas aeruginosa biofilm. Here we evaluated effects of iron depletion on the antimicrobial activity of ceftazidime, tobramycin and ciprofloxacin against planktonic and biofilm Pseudomonas aeruginosa.

Methods: We tested the sensitivities of wild-type PAO1, type-IV pilus mutant PAO-DeltapilHIJK and the quorum-sensing mutant PAO-JP2 P.

Synergistic effects of aminoglycosides and fosfomycin on Pseudomonas aeruginosa in vitro and biofilm infections in a rat model.

Objectives: To study the in vitro and in vivo efficacy of aminoglycosides against Pseudomonas aeruginosa, either alone or in combination with fosfomycin.

Methods: Using an in vitro study to assess inhibition of the growth of P. aeruginosa, MIC(90) and MIC(50) values of amikacin, gentamicin, netilmicin, tobramycin and isepamicin were determined, either alone or in combination with fosfomycin, and then the fractional inhibitory concentration index was calculated.

[Antitumor effect of polysaccharides from cactus pear fruit in S180-bearing mice].

Background & Objective: Polysaccharide components of some traditional Chinese medicine have certain antitumor effects and can promote immune responses. Extractions from cactus pear fruit can inhibit the proliferation of cervical cancer, ovary cancer and bladder cancer cells, and suppress the growth of ovarian cancer in mice. This study was to observe the antitumor effect of polysaccharides extracted from cactus pear fruit in S180-bearing mice.

Antibacterial activity of allicin alone and in combination with beta-lactams against Staphylococcus spp. and Pseudomonas aeruginosa.

Allicin is one of the most effective compounds isolated from garlic showing antibacterial activity. Determination of MIC alone or in combination with cefazolin/oxacillin against Staphylococcus spp. or with cefoperazone against Pseudomonas aeruginosa showed that allicin alone did not have good antibacterial activity (MIC90>512 microg/ml) but it facilitated antibacterial activity of all three beta-lactams tested at subinhibitory concentrations.

[Mutant prevention concentrations of fluoroquinolones for Staphylococcus aureus].

Objective: To establish a method to measure mutant prevention concentration (MPC) in vitro, and to measure MPC of fluoroquinolones for staphylococcus aureus.

Methods: The staphylococcus aureus strain ATCC25923 and 20 ciprofloxacin-susceptible clinical isolates were enriched in broth, and the bacterial concentrations were adjusted to 10(10) colony forming units per milliliter. The minimal inhibitory concentration (MIC), MIC for 99% of input cells (MIC99), provisional MPC (MPCpr) and MPC of moxifloxacin, gatifloxacin, pasufloxacin and ciprofloxacin for staphylococcus aureus were determined by agar plates dilution method.