Publications by authors named "Bei Shu"
Microb Cell Fact
May 2024
Article Synopsis
- Sesterterpenoids like ophiobolins have potential medicinal value due to their cytotoxic activity, but there's a need for more of them for drug development.
- A metabolic engineering strategy was developed using yeast (Saccharomyces cerevisiae) to enhance the biosynthesis of ophiobolins, achieving a yield of 5.1 g/L of ophiobolin F.
- The research led to the identification of a new cytotoxic intermediate and successful production of ophiobolin U, establishing yeast as a valuable cell factory for producing sesterterpenoids for medicinal use.
