Characteristics of immunisation support programmes in Canada: a scoping review and environmental scan.

Objective: To identify, characterise and map the existing knowledge about programmes that provide immunisation support to Canadians and barriers and facilitators to their delivery.

Design: Scoping review and environmental scan.

Introduction: Vaccine hesitancy may be associated with unmet support needs of individuals.

Interaction between Chinese medicine and digoxin: Clinical and research update.

Digoxin is one of the most widely and commonly used cardiac drug, which plays an irreplaceable role in treating heart failure and arrhythmia. stipulates that the effective range of digoxin plasma concentration is 0.5-2.

Complement C3 and Activated Fragment C3a Are Involved in Complement Activation and Anti-Bacterial Immunity.

In the complement system, C3 is a central component in complement activation, immune defense and immune regulation. In all pathways of complement activation, the pivotal step is conversion of the component C3 to C3b and C3a, which is responsible to eliminate the pathogen and opsonization. In this study, we examined the immunological properties of C3 and its activated fragment C3a from Japanese flounder () (PoC3 and PoC3a), a teleost species with important economic value.

miR-296-5p Inhibits the Secretion of Pulmonary Surfactants in Pulmonary Epithelial Cells via the Downregulation of Wnt7b/-Catenin Signaling.

Neonatal respiratory distress syndrome (NRDS) is a common disease that occurs in premature infants. However, the mechanisms underlying the disease remain unclear. microRNAs (miRNAs) have been indicated to play a crucial role in the development of NRDS.

The Translocation and Assembly Module (TAM) of Is Essential for Stress Resistance and Host Infection.

Translocation and assembly module (TAM) is a protein channel known to mediate the secretion of virulence factors during pathogen infection. is a Gram-negative bacterium that is pathogenic to a wide range of farmed fish and other hosts including humans. In this study, we examined the function of the two components of the TAM, TamA and TamB, of (named and , respectively).

Prevention of systemic inflammation and neuroprotective effects of Qingda granules against angiotensin II-mediated hypertension.

Qingxuan Jiangya Decoction (QXJYD), prescribed by academician Ke-ji Chen, has long been used as a Traditional Chinese Medicine formula in blood pressure control and has achieved good clinical outcomes in hypertensive patients. Qingda granules (QDGs), which is a formula simplified from QXJYD, might serve as a novel anti-hypertensive pharmaceutical. However, the functional mechanism of QDGs remains unclear.

The trypsin-like serine protease domain of Paralichthys olivaceus complement factor I regulates complement activation and inhibits bacterial growth.

In mammals, complement factor I (CFI) is a serine protease in serum and plays a pivotal role in the regulation of complement activation. In the presence of cofactor, CFI cleaves C3b to iC3b, and further degrades iC3b to C3c and C3d. In teleost, the function of CFI is poorly understood.

Bis(nitrato-κO)(3-oxapentane-1,5-diamine-κN,O,N')zinc(II).

In the title compound, [Zn(NO(3))(2)(C(4)H(12)N(2)O)], the Zn(II) atom is N,O,N'-chelated by a 3-oxapentane-1,5-diamine ligand and is further coordinated by two nitrate anions in a distorted trigonal-bipyramidal geometry. Inter-molecular N-H⋯O hydrogen bonding is present in the crystal structure. A short O⋯O contact of 2.