Standardization of the analytical procedure based on deep eutectic solvent for the extraction and measurement of tricyclic antidepressants drugs in post-mortem blood samples.

Measuring drugs in post-mortem blood samples is one of the most important challenges in forensic medicine. The development of sensitive analytical techniques for the measurement of drugs in biological samples is of great use in forensic medicine. In this research an easy, safe and environmental friendly vortex-assisted liquid phase microextraction (VA-LPME) based on deep eutectic solvent (DES) followed by high performance liquid chromatography-ultraviolet detector (HPLC-UV) was developed for the extraction, preconcentration and analysis of tricyclic antidepressants drugs (TCAs) in post-mortem blood samples.