Publications by authors named "Behzad Bokanizad"
Article Synopsis
- - The goal of pathway analysis is to pinpoint which biological pathways are affected when a system experiences changes, like diseases or treatments, but existing methods treat pathways separately rather than as interconnected.
- - This study introduces three new pathway analysis methods that evaluate pathways in a more holistic way by analyzing communication and overlaps between them at a system level.
- - When tested against other established methods on multiple datasets, the new approaches significantly improved the ranking and statistical significance of the affected pathways by considering their interdependencies.
The goal of pathway analysis is to identify the pathways significantly impacted in a given phenotype. Many current methods are based on algorithms that consider pathways as simple gene lists, dramatically under-utilizing the knowledge that such pathways are meant to capture. During the past few years, a plethora of methods claiming to incorporate various aspects of the pathway topology have been proposed.
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