Nicotine, as a novel tolerogenic adjuvant, enhances the efficacy of immunotherapy in a mouse model of allergic asthma.

An increasing trend in the incidence of allergic diseases including asthma and related morbidity and mortality is observed worldwide during the last decades. Allergen-specific immunotherapy is suggested for the treatment of some allergic diseases; nevertheless, there is always a menace of uncommon, but life-treating reactions due to increasing the administration of allergen extract doses. Hence, improving its efficacy may reduce the required doses as well as the risk of such reactions.

Evaluation of the efficacy of isopathic immunotherapy in the treatment of allergic asthma in BALB/C mice.

: Homeopathy is a therapeutic method based on the fundamental principle of "like cures like." Homeopathic remedies are extremely dilute but involve vigorous shaking at each dilution. Isopathy is one approach of homeopathy, in which the causative agents or products of a disease are used to treat the same disease.

Evaluation of the efficacy of nicotine in treatment of allergic asthma in BALB/c mice.

Nicotine, an nAChR agonist, shows prominent anti-inflammatory properties, and some studies have illustrated its suppressive effects on inflammation. Here, we have examined whether nicotine as a medicine may have beneficial effects on the treatment of asthma in a mouse model of allergic asthma. BALB/c mice were sensitized with OVA and alum.

Mast cells improve functional recovery of transected peripheral nerve: A novel preliminary study.

Background: Employment of regenerative properties of cells at the service of nerve repair has been initiated during recent decades. Effects of local transplantation of bone marrow-derived mast cells on peripheral nerve regeneration were studied using a rat sciatic nerve transection model.

Materials And Methods: A 10-mm sciatic nerve defect was bridged using a conduit chitosan-based hybrid conduit filled with BMMCs in BMMC group.

Effect of prenatal stress on density of NMDA receptors in rat brain.

N-methyl-D-aspartate (NMDA) receptors are important excitatory receptors which contribute to many brain functions. Altered NMDA receptor levels cause maldevelopment of corticostriatal and corticolimbic pathways, which is a neurobiological predisposing factor for development of epilepsy, schizophrenia and other idiopathic psychotic disorders. It was hypothesized that prenatal stress could play a role in pathophysiology of these disorders by affecting expression of the receptors through releasing corticosterone.

Mandibular plasmocytoma with sun-ray periosteal reaction: A unique presentation.

Introduction: Solitary plasmocytoma is a rare plasmacytic cell tumor, which occurs in the head and neck region and rarely involves the mandible.

Presentation Of Case: We present a unique radiographic presentation of solitary bone plasmocytoma (SBP) occurring in the Jaw. A 63-year-old male presented with the left mandibular swelling and on the conventional radiograph we noticed a lytic lesion with a sunray periosteal reaction.

Periosteal osteosarcoma of the fifth metatarsal: a rare pedal tumor.

Periosteal osteosarcoma is a rare pedal chondroblastic osteosarcoma that rarely involves the medullary bone. In the present report, we describe the case of a woman who presented with a periosteal osteosarcoma localized to her left foot.

Extranodal diffuse large B-cell lymphoma confined to liver in a kidney transplant recipient.

Posttransplant lymphoproliferative disorder (PTLD) is a well-documented complication that arises as a result of immunosuppression in the setting of solid organ or bone marrow transplantation. The disorder may be subtle and/or extranodal. We report a patient with extranodal lymphoma following kidney transplantation who had successful treatment with surgery and chemotherapy.

Effect of active vitamin D on expression of co-stimulatory molecules and HLA-DR in renal transplant recipients.

Objectives: Full activation of T cells requires 2 distinct but synergistic signals. The first is the T-cell antigen receptor, which is antigen specific, and the second is activation of co-stimulatory signals. Active vitamin D (1, 25-dihydroxyvitamin D3) decreases T-cell activation and proliferation, inhibits differentiation and maturation of dendritic cells, and induces tolerogenic dendritic cells.