The Effect of Vitamin B in the Prevention of Hematological Adverse Effects of Linezolid in Patients with Chronic Osteomyelitis: A Randomized Double-Blind Placebo-Controlled Clinical Trial.

Background: Due to the contradictory results of the effects of Vitamin B6 in reducing the hematotoxic effects of linezolid, the present study aimed to investigate the possible role of Vitamin B6 administration in reducing linezolid-related hematological toxicities in patients with chronic osteomyelitis.

Materials And Methods: In a randomized double-blind placebo-controlled clinical trial, patients with chronic osteomyelitis were randomly divided into two groups (n = 40 each): the intervention group received Vitamin B40 mg twice daily from the beginning of treatment with linezolid and the control group received placebo with linezolid, both for 21 days. Blood variables including hemoglobin (Hb), white blood cells (WBC), and platelets (PLT) were measured at baseline and at the end of the 1, 2, and 3 weeks (days 7, 14, and 21) of the intervention.

Crimean-Congo hemorrhagic fever virus as a nosocomial pathogen in Iran.

Crimean-Congo hemorrhagic fever (CCHF) is a viral disease with several different modes of transmission. We describe the manifestations, outcome, and likely modes of transmission for three nosocomial cases. All three cases were healthcare workers (two men and one woman).