Crocetin suppresses the growth and migration in HCT-116 human colorectal cancer cells by activating the p-38 MAPK signaling pathway.

Background And Purpose: Crocetin is a natural antioxidant that is found in the crocus flower and (fruit). Previous studies have reported its anticancer activity both and . In addition, crocetin suppresses the growth and migration of human colorectal cancer cells, however, its mechanism of action remains to be elucidated.

Curcumin modulates the angiogenic potential of human endothelial cells via FAK/P-38 MAPK signaling pathway.

Many phyto-compounds are found to have anti-angiogenesis property. Curcumin, a natural polyphenol, has been used as medicinal plant for years with different biological activities. Here, we investigated the effect of curcumin on angiogenesis potential of human endothelial cells.