Hearing the unheard: Fundamentals of acoustic emission signals as predictors of total hip arthroplasty implant loosening.

Implant loosening remains a primary cause of failure of total hip arthroplasty (THA) and is often detected late, when pain occurs. Acoustic emission (AE) analysis is a promising method for early loosening detection, on the supposition that relative movements at the bone-implant interface induce detectable AE signals. To distinguish loosening-induced AE signals from those of stable THA components in vitro investigations are necessary.

Assessing Whether Negative Parenting Cognitions Bias Parent Report of Preschoolers' Externalizing Symptoms: A Regularized Moderated Non-Linear Factor Analysis Approach.

Parent report is frequently used to assess children's psychopathology, however, researchers have expressed concerns about the validity of parent reports. Some parental characteristics, attitudes, or beliefs may systematically bias a parent's report of their child's behaviors and functioning. Informed by social information processing models of parenting risk, parents with more difficulties reflecting on and interpreting their children's behavior may be at risk for less accurate reports.

Retrospective Impact of COVID-19 Pandemic on Primary Breast Cancer Care.

Background: The COVID-19 pandemic has transformed breast cancer care for patients and healthcare providers. Circumstances varied greatly by region and hospital, depending on COVID-19 prevalence, case mix, hospital type, and available resources. These challenges have disrupted screening programs and have been particularly distressing for both women with a breast cancer diagnosis and their providers.

Antithrombin III Levels and Outcomes Among Patients With Trauma.

Importance: Patients with trauma exhibit a complex balance of coagulopathy manifested by both bleeding and thrombosis. Antithrombin III is a plasma protein that functions as an important regulator of coagulation. Previous studies have found a high incidence of antithrombin III deficiency among patients with trauma.

Isolation of Single Circulating Tumor Cells Using VyCAP Puncher System.

Tumor heterogeneity has a major role in the development of tumor evasion and resistance to treatments. To study and understand the intrinsic heterogeneity of cancer cells, the use of single-cell isolation technology has had a major boost in recent years, gaining ground to bulk analysis in the study of solid tumors. In the liquid biopsy field, the use of technologies for single-cell analysis has represented a major advance in the study of the heterogeneity of circulating tumor cells (CTCs), providing relevant information about therapy-resistant CTCs.

Principal component analysis of a swine injury model identifies multiple phenotypes in trauma.

Background: Trauma is the third leading cause of death in the United States and the primary cause of death for people between the ages of 1 year and 44 years. In addition to tissue damage, trauma may also activate an inflammatory state known as trauma-induced coagulopathy (TIC) that is associated with clotting malfunctions, acidemia, and end-organ dysfunction. Prior work has also demonstrated benefit to acknowledging the type and severity of endothelial injury, coagulation derangements, and systemic inflammation in the management of trauma patients.

A Meta-Analysis of the Influence of Cue Valence on Overgeneral Memory and Autobiographical Memory Specificity Among Youth.

Overgeneral memory (OGM), or difficulty recalling specific memories when recounting autobiographical events, is associated with psychopathology. According to functional avoidance theory, OGM-or reduced autobiographical memory specificity (AMS)-may serve as an emotion regulation strategy that aids in the avoidance of painful, negative memories (Sumner, 2012; Williams et al., 2007).

Preventing child welfare reinvolvement: The efficacy of the Reminiscing and Emotion Training intervention.

Child maltreatment is a pathogenic relational experience that creates risk for physical and psychological health difficulties throughout the lifespan. The Reminiscing and Emotion Training intervention (RET) was developed to support maltreated children's healthy development by improving parenting behavior among maltreating mothers. Here, we evaluated whether RET was associated with reductions in child welfare reinvolvement over the course of two years.

Validation of the Parental Reflective Functioning Questionnaire among maltreating and nonmaltreating mothers.

The Parental Reflective Functioning Questionnaire (PRFQ; Luyten et al., 2017) is a central measure of parental reflective functioning (i.e.

Hardness Assessment Considering Nitrided Layers Based on Tempering Tests for Numerical Wear Prediction for Forging Processes.

The nitriding of forging tools is an industrially established standard used to increase the hardness of the tool surface layer and reduce wear. However, this modification of the tool surface layer, as well as the microstructural changes that occur during this operation due to the thermo-mechanical load, cannot be considered during wear calculations with the widely used Archard wear model in the context of FE simulations. Based on previous work, this study further develops two tempering tests for the investigation of the hardness evolution of two nitride profiles based on H11 tool steel.

Latent classes in preschoolers' internal working models of attachment and emotional security: Roles of family risk.

Children's relationships inform their internal working models (IWMs) of the world around them. Attachment and emotional security theory (EST) emphasize the importance of parent-child and interparental relationships, respectively, for IWM. The current study examined (a) data-driven classes in child attachment and emotional security IWM, (b) associations between IWM classes and demographic variables, maltreatment, intimate partner violence (IPV), and maternal depressive symptoms, and (c) consistency in attachment and emotional security IWM classes, including as a function of maltreatment, IPV, and maternal depressive symptoms.

Characterization of the Interface between Aluminum and Iron in Co-Extruded Semi-Finished Products.

Within the framework of the Collaborative Research Center 1153, we investigated novel process chains for the production of bulk components with different metals as joining partners. In the present study, the co-extrusion of coaxially reinforced hollow profiles was employed to manufacture semi-finished products for a subsequent die-forging process, which was then used for the manufacture of hybrid bearing bushings. The hybrid hollow profiles, made of the aluminum alloy EN AW-6082 paired with either the case-hardening steel 20MnCr5, the stainless steel X5CrNi18-10, or the rolling bearing steel 100Cr6, were produced by Lateral Angular Co-Extrusion.

FFP maintains normal coagulation while Kcentra induces a hypercoagulable state in a porcine model of pulmonary contusion and hemorrhagic shock.

Background: Moderate injury can lead to a coagulopathy. Fresh frozen plasma (FFP) corrects coagulopathy by means of a balanced array of clotting factors. We sought to compare the late effects of FFP and a prothrombin complex concentrate (PCC) on the coagulopathy of trauma using a porcine model of pulmonary contusion (PC) and hemorrhagic shock (HS) designed to evaluate the organ protective effects of these treatments.

Multiparametric Circulating Tumor Cell Analysis to Select Targeted Therapies for Breast Cancer Patients.

Background: The analysis of liquid biopsies, e.g., circulating tumor cells (CTCs) is an appealing diagnostic concept for targeted therapy selection.

A qualitative exploration of families' experiences and resilience factors during the COVID-19 pandemic.

The COVID-19 pandemic has prompted widespread changes and challenges worldwide. In the context of the early months of the pandemic, the current study utilized thematic analysis to assess parents' ( = 13) perspectives of need for resources to foster their family's wellbeing. Five themes emerged: Information Deficits, Need for More Instrumental Supports, Frustration and Worry, Resources Promoting Resilience, and Positive Perspective Shift.

Child internalizing symptoms during the COVID-19 pandemic among maltreating and non-maltreating families: Examining the effects of family resources and the Reminiscing and Emotion Training intervention.

Background: The effects of the COVID-19 pandemic on child functioning have been especially pronounced among low-income families. Protective factors, including sensitive reminiscing and sufficient family resources, may reduce the negative effects of the pandemic on child adjustment.

Objective: The current study investigated how family resources during the pandemic, race, maltreatment, and pre-pandemic involvement in an emotion socialization intervention (M = 4.

Genetic analysis of single disseminated tumor cells in the lymph nodes and bone marrow of patients with head and neck squamous cell carcinoma.

Considering the limited information on the biology and molecular characteristics of disseminated tumor cells (DTCs) in head and neck squamous cell carcinoma (HNSCC), we examined the genomic alterations in DTCs from HNSCCs and their potential clinical relevance. To analyze both the lymphatic and hematogenous routes of tumor cell dissemination, we investigated samples from lymph nodes (LNs) and bone marrow (BM) of 49 patients using immunofluorescence double staining for epithelial cells expressing cytokeratin 18 (KRT18) and/or epithelial cell adhesion molecules (EpCAM, CD326). The identified marker-positive cells were isolated by micromanipulation followed by single-cell whole-genome amplification and metaphase-based comparative genomic hybridization (mCGH) to determine genome-wide copy number alterations.

Finite Element and Finite Volume Modelling of Friction Drilling HSLA Steel under Experimental Comparison.

Friction drilling is a widely used process to produce bushings in sheet materials, which are processed further by thread forming to create a connection port. Previous studies focused on the process parameters and did not pay detailed attention to the material flow of the bushing. In order to describe the material behaviour during a friction drilling process realistically, a detailed material characterisation was carried out.

GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy.

Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa). The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress and DNA damage in tumor cells. However, PCa radiocurability can be impeded by tumor resistance mechanisms and normal tissue toxicity.

Massive transfusions and severe hypocalcemia: An opportunity for monitoring and supplementation guidelines.

Background: Massive transfusion protocols (MTPs) are associated with severe hypocalcemia, contributing to coagulopathy and mortality in severely injured patients. Severity of hypocalcemia following massive transfusion activation and appropriate treatment strategies remain undefined.

Study Design And Methods: This was a retrospective study of all MTP activations in adult trauma patients at a Level 1 trauma center between August 2016 and September 2017.

Characterization and Modeling of Nano Wear for Molybdenum-Based Lubrication Layer Systems.

As a result of global economic and environmental change, the demand for innovative, environmentally-friendly technologies is increasing. Employing solid lubricants in rolling contacts can reduce the use of environmentally harmful greases and oils. The aim of the current research was the development of a solid lubricant system with regenerative properties.

Fringe Projection Profilometry in Production Metrology: A Multi-Scale Comparison in Sheet-Bulk Metal Forming.

Fringe projection profilometry in combination with other optical measuring technologies has established itself over the last decades as an essential complement to conventional, tactile measuring devices. The non-contact, holistic reconstruction of complex geometries within fractions of a second in conjunction with the lightweight and transportable sensor design open up many fields of application in production metrology. Furthermore, triangulation-based measuring principles feature good scalability, which has led to 3D scanners for various scale ranges.

Longitudinal Effects of Reminiscing and Emotion Training on Child Maladjustment in the Context of Maltreatment and Maternal Depressive Symptoms.

Exposure to child maltreatment and maternal depression are significant risk factors for the development of psychopathology. Difficulties in caregiving, including poor emotion socialization behavior, may mediate these associations. Thus, enhancing supportive parent emotion socialization may be a key transdiagnostic target for preventive interventions designed for these families.

Challenges in the Forging of Steel-Aluminum Bearing Bushings.

The current study introduces a method for manufacturing steel-aluminum bearing bushings by compound forging. To study the process, cylindrical bimetal workpieces consisting of steel AISI 4820 (1.7147, 20MnCr5) in the internal diameter and aluminum 6082 (3.

Initial measurement of beryllium-9 using high-resolution inductively coupled plasma mass spectrometry allows for more precise applications of the beryllium isotope system within the Earth Sciences.

Rationale: Precise and accurate determination of the ratio of the cosmogenic nuclide Be to the stable isotope Be ( Be/ Be) is needed across multiple fields of research within the Earth Sciences. Current techniques used to measure the Be content of geological materials generally require a large amount of sample or solution aliquot and present a large range of analytical precisions.

Methods: A range of geological reference materials underwent whole-rock dissolution and "strong" (0.