Pyrazole derivatives as antileishmanial agents: Biological evaluation, molecular docking study, DFT analysis and ADME prediction.

Leishmaniasis is a parasitic disease that is commonly found in tropical and sub-tropical regions. Currently, there is no protective antileishmanial vaccine, and the available clinical drugs have serious side effects. On the other hand, due to the emergence of multidrug-resistant strains of the causative pathogens, the study and design of novel antileishmanial agents is urgently needed.

Exogenous methyl jasmonate affects genes involved in monoterpene biosynthetic pathway, phyto-biochemical accumulation, and enzymatic activity of Satureja hortensis L.

Satureja hortensis L. (SH) is a medicinal and aromatic herb utilized markedly in the food, pharmaceutical, and cosmetic industries because of its specific secondary metabolites (SMs), especially monoterpenoids. However, the impact of elicitors on the expression of monoterpene synthase genes in SH remains unexplored.