Mixed-Linker Zr-Metal-Organic Framework with Improved Lewis Acidic Sites for CO Fixation Reaction Catalysis.

Applying the mixed-linker strategy in synthesizing metal-organic frameworks (MOFs) has drawn considerable attention as a heterogeneous catalyst owing to their easy synthesis and different functional ligands in their frameworks. Following this strategy, we have developed a mixed linker Zr(IV)-based MOF, [ZrO(OH)(FUM)(PZDC-NO)] (PZDC-NO = 4-nitro-3,5-pyrazoledicarboxylic acid, FUM = fumaric acid) denoted as MOF-801(PZDC-NO) synthesized via this strategy which possess an electron-withdrawing group (-NO) on secondary linkers. The MOF-801(PZDC-NO) has been fully characterized via various analyses, such as Fourier transform infrared, powder X-ray diffraction, C/H nuclear magnetic resonance, XPS, TGA, and N adsorption/desorption, SEM, EDX, etc.

Converting a Non-Porous Rare-Earth Metal-Organic Framework into a Porous Yttrium-Based NHUiO-66 Network via a Linker Exchange Approach.

The solvent-assisted linker exchange (SALE) method was used to produce amino-functionalized yttrium-based UiO-66 [NHUiO-66(Y)], which is not obtainable via a direct synthetic method. Remarkably, SALE not only produced relatively highly porous NHUiO-66(Y) from completely non-porous 3,3-bpdc-Y but also changed the network topology from 8-connected in 3,3-bpdc-Y to 12-connected in NHUiO-66(Y). Based on our knowledge, this is one of the rare cases where SALE changes the whole network topology of the resulting metal-organic framework.

Plasma Complement C1q/tumor necrosis factor-related protein 15 concentration is associated with polycystic ovary syndrome.

Polycystic ovarian syndrome (PCOS) is a common poignant endocrine disorder affecting women, posing a close association with metabolic syndrome and obesity. Existing literature characterizes PCOS with deranged levels of several adipokines and myokines. CTRP15 is a paralogue of adiponectin, mainly expressed by skeletal muscles, and plays a key role in insulin, glucose, and lipid metabolism.

Chitosan/PVA/Doxycycline Film and Nanofiber Accelerate Diabetic Wound Healing in a Rat Model.

In this study, we evaluated the effects of nanofiber and film polymers with doxycycline for treating a wound in a diabetic rat model. 108 male rats were divided into six groups, the control group, the diabetic control, and the groups were diabetic rats receiving different wound dressing. At the 3rd, 7th, and 14th days, macroscopic/histologic imaging and tissue sampling were performed.

Electrochemical Applications of Ferrocene-Based Coordination Polymers.

Ferrocene and its derivatives, especially ferrocene-based coordination polymers (Fc-CPs), offer the benefits of high thermal stability, two stable redox states, fast electron transfer, and excellent charge/discharge efficiency, thus holding great promise for electrochemical applications. Herein, we describe the synthesis and electrochemical applications of Fc-CPs and reveal how the incorporation of ferrocene units into coordination polymers containing other metals results in unprecedented properties. Moreover, we discuss the usage of Fc-CPs in supercapacitors, batteries, and sensors as well as further applications of these polymers, for example in electrocatalysts, water purification systems, adsorption/storage systems.

The renin-angiotensin system in cutaneous hypertrophic scar and keloid formation.

Hypertrophic scar and keloid are two types of fibroproliferative conditions that result from excessive extracellular matrix production. The underlying pathological mechanism is not entirely clear. Activation of the renin-angiotensin system (RAS) is associated with fibrosis in various organs.

Detection of Angiotensin II and AT Receptor Concentrations in Keloid and Hypertrophic Scar.

Keloid and hypertrophic scars (HTS) are formed by excessive collagen formation. Angiotensin II, through the AT receptor, plays an important role in extracellular matrix production. However, less is known about angiotensin II and AT receptor concentrations in HTS and keloid tissues.

Losartan ointment relieves hypertrophic scars and keloid: A pilot study.

Keloid and hypertrophic scars are two types of fibrosis caused by extracellular matrix overexpression, and angiotensin II via AT receptor is known to play a key role in stimulation of fibrosis. A pilot placebo controlled single blind study was carried out on patients with hypertrophic scars and keloids. A total of 37 adult volunteers were randomly assigned into losartan 5% or placebo treatment groups.