A randomized clinical trial evaluating Hydralazine's efficacy in early-stage Alzheimer's disease: The EHSAN Study.

Alzheimer's Disease (AD), a neurodegenerative disorder escalating worldwide, remains incurable with existing interventions merely mitigating symptoms. Hydralazine, an antihypertensive agent, has displayed neuroprotective potential in AD animal models via amplification of mitochondrial functionality and stimulation of stress management and repair pathways. Nevertheless, its effectiveness and tolerability in human AD cohorts are yet to be confirmed.

Comparison of fecal and oral collection methods for studies of the human microbiota in two Iranian cohorts.

Background: To initiate fecal and oral collections in prospective cohort studies for microbial analyses, it is essential to understand how field conditions and geographic differences may impact microbial communities. This study aimed to investigate the impact of fecal and oral sample collection methods and room temperature storage on collection samples for studies of the human microbiota.

Results: We collected fecal and oral samples from participants in two Iranian cohorts located in rural Yazd (n = 46) and urban Gonbad (n = 38) and investigated room temperature stability over 4 days of fecal (RNAlater and fecal occult blood test [FOBT] cards) and comparability of fecal and oral (OMNIgene ORAL kits and Scope mouthwash) collection methods.

Infertility and physical activity: A cross-sectional study of women living in Yazd aged 20-49 yr, 2014-2015.

Background: Changes in the state of energy balance owing to changes in physical activity (PA) may affect the reproductive system.

Objective: the aim of this study was to assess the association between PA and infertility of women living in Yazd 2014 - 2015.

Materials And Methods: The study method was analytical cross-sectional on the Yazd Health Study (YaHS) data which was conducted on 10,000 people.