Hydration and percutaneous absorption: I. Influence of hydration on alkanol permeation through hairless mouse skin.

A method to study the influence of hydration on skin permeability where the skin is immersed in saline for up to 30 hr and under circumstances where a steady state rate of permeation can be established in several minutes is indicated. These circumstances allow multiple, sequential runs over a period where the permeability coefficients of some chemicals are gradually changing. It has been found that the permeabilities of water, methanol and ethanol are little affected by such hydration.

Permeability of thermally damaged skin: I. Immediate influences of 60 degrees C scalding on hairless mouse skin.

Freshly sacrificed hairless mice were burned dorsally by direct contact with 60 degrees C water for periods ranging from 15 seconds to 8 min. Wounds ranging in degree from superficial epidermis damage to injury penetrating well into subcutaneous musculature were inflicted. Burned skin sections and reference abdominal skin sections were excised, placed in diffusion cells and investigated with regards to their permeabilities to water, methanol, ethanol, n-butanol and n-octanol.

Permeation of hairless mouse skin I: Experimental methods and comparison with human epidermal permeation by alkanols.

The permeation of intact hairless mouse skin by alkanols was studied. The method is described, and data for the quasi-steady-state and nonstationary-state aspects of mass transfer are given. Partitioning data also are presented.

Vaginal drug absorption in rhesus monkeys I: development of methodology.

Earlier reports from these laboratories described a procedure for determining vaginal drug absorption in the rabbit based upon a perfusion system, and data on the vaginal absorption of the straight-chain aliphatic alcohols and carboxylic acids were given. These studies have been extended to the rhesus monkey. Rib-cage-type cells were designed for intravaginal insertion through the vulval orifice and to fit the specific dimensions of the monkey vagina.

Improved taste acceptability for an oral hyperalimentation dosage form.

Various flavoring agents were evaluated as to their ability to improve the taste acceptability of Vivovnex-HN, a potent oral hyperalimentation diet. Several imitation flavors were incorporated into the Vivonex-HN powder in different concentrations with and without an artificial sweetener. The mixtures were rated by a taste panel.

Aqueous solubility of 14C-triamcinolone acetonide.

The blue tetrazolium colorimetric assay has often been employed in the analysis of corticosteroids. However, the reaction between blue tetrazolium and corticosteroids partly depends on the apparent pH of the system. In an earlier study of the temperature dependence of the solubility and dissolution of triamcinolone acetonide in aqueous dissolution media (distilled water and 0.