Transfusion History Is More Predictive Than Serum Ferritin Level in Prediction of Hypothyroidism in Transfusion Dependent Thalassemia.

Transfusion dependent thalassemia (TDT) patients require a regular blood transfusion to survive. Without adequate transfusion support, they suffer many complications, and have a short life span. Near about 200 milligrams of iron remains within a single Red cell concentrate (RCC) unit.

Investigation of structural, optical, antibacterial, and dielectric properties of sol-gel and biosynthesized TiO nanoparticles.

This study explored the structural, optical, antibacterial, and dielectric properties of TiO nanoparticles synthesized using two distinct approaches: sol-gel and biosynthesis. Density functional tight binding (DFTB+) and density functional theory (DFT) calculations were employed alongside experimental techniques to gain a comprehensive understanding of the electronic-property relationships. peel extract was utilized for the biosynthesis method.

Use of posteroanterior reference guides for bone block or coracoid process transfer in anterior glenohumeral instability: a cadaveric study of the relationship to the suprascapular nerve.

Background: Iatrogenic suprascapular nerve injury secondary to posterior drilling or screw penetration is a recognized complication of bone block or coracoid process transfers for anterior glenohumeral instability. We present the first cadaveric study that assesses the safety of posteroanterior reference guides and quantifies the relationship of the suprascapular nerve to posterior glenoid fixation with suture buttons.

Methods: Anterior glenoid bone block reconstruction with suture buttons utilizing a posteroanterior reference guide was performed in 10 fresh frozen cadavers via a posterior portal.

Exploring the Connections: Autophagy, Gut Microbiota, and Inflammatory Bowel Disease Pathogenesis.

Inflammatory Bowel Disease (IBD), which includes Crohn's disease and ulcerative colitis, represents a complex and growing global health issue with a multifaceted origin. This review delves into the intricate relationship between gut microbiota, autophagy, and the development of IBD. The gut microbiota, a diverse community of microorganisms, plays a vital role in maintaining gut health, while imbalances in this microbial community, known as dysbiosis, are linked to IBD.

Unveiling the Involvement of Herpes Simplex Virus-1 in Alzheimer's Disease: Possible Mechanisms and Therapeutic Implications.

Viruses pose a significant challenge and threat to human health, as demonstrated by the current COVID-19 pandemic. Neurodegeneration, particularly in the case of Alzheimer's disease (AD), is significantly influenced by viral infections. AD is a neurodegenerative disease that affects people of all ages and poses a significant threat to millions of individuals worldwide.

Myelin Lipid Alterations in Neurodegenerative Diseases: Landscape and Pathogenic Implications.

Lipids, which constitute the highest portion (over 50%) of brain dry mass, are crucial for brain integrity, energy homeostasis, and signaling regulation. Emerging evidence revealed that lipid profile alterations and abnormal lipid metabolism occur during normal aging and in different forms of neurodegenerative diseases. Moreover, increasing genome-wide association studies have validated new targets on lipid-associated pathways involved in disease development.

Computational analysis of controlled drug release from porous polymeric carrier with the aid of Mass transfer and Artificial Intelligence modeling.

Controlled release of a desired drug from porous polymeric biomaterials was analyzed via computational method. The method is based on simulation of mass transfer and utilization of artificial intelligence (AI). This study explores the efficacy of three regression models, i.

The Distribution of Respiratory Viral Pathogens Among the Symptomatic Respiratory Tract Infection Patients From Dhaka City in the Pre-COVID-19 Pandemic Era.

Rapid and accurate diagnosis is crucial for determining the etiology and, perhaps, effectively treating and preventing viral respiratory infections. A multiplex quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay⁠⁠⁠⁠⁠⁠⁠ was utilized to determine the prevalence of viral etiology in cases of acute respiratory tract infections (ARTIs). Outpatient department (OPD) and intensive care unit (ICU) patients with fever and respiratory symptoms were enrolled from December 2018 to April 2020.

Nurse-led framework to improve the safety and quality of residential aged care (HIRAID® Aged Care): protocol for a stepped-wedge cluster randomised controlled trial.

Background: The health issues experienced by older people can often be severe and complex, and an increasing number are using residential aged care services to meet their care needs. High-quality nursing care is fundamental to the health and safety of aged care residents and is contingent on nurses' accurate assessment, informed decision-making, and delivery of timely interventions. However, the role of the aged care nurse is often challenging, impeded by factors such as understaffing, high workloads, and a lack of access to clinical infrastructure and resources.

Effects of Titanium Dioxide Nanoparticles on Chick Embryo: Immunomodulatory, Hepatic and Biochemical Alterations.

Background: The utilization of titanium dioxide nanoparticles (TiO NPs) has significantly increased across various industries.

Objectives: This study rigorously explored the impact of TiO NPs exposure on chicken embryos, focusing particularly on alterations in the immune system, liver functionality and key biochemical markers.

Methods: The study involved three groups of 30 eggs each, subjected to increasing doses of TiO NPs: Group C (control), Group T1 (150 µg/mL) and Group T2 (300 µg/mL).

Integration of BWT scrambling and data compression in an innovative system enhances protection and versatile management of sensor feeds (SEC).

The proposed Sensor Data Encryption with Compression (SEC) system is presented as an innovative solution for sensor data processing, aiming to achieve optimal efficiency while improving security and adaptability by integrating robust cryptography with advanced compression techniques. The system's objective is to create a reliable framework for managing sensitive sensor data by effectively tackling challenges in data processing through a balanced combination of strong cryptography and sophisticated compression methods. The SEC system utilizes advanced encryption and compression techniques, including the scrambling of Burrows-Wheeler Transform (BWT), Move-to-Front (MTF) encoding, Run-Length Encoding (RLE), and Huffman coding, to attain exceptional compression efficiency while maintaining data integrity.

Correction: Understanding patient and family experiences of critical care in Bangladesh and India: What are the priority actions to promote person-centred care?

[This corrects the article DOI: 10.1371/journal.pgph.

Inflammatory signaling pathways in Alzheimer's disease: Mechanistic insights and possible therapeutic interventions.

The complex pathophysiology of Alzheimer's disease (AD) poses challenges for the development of therapies. Recently, neuroinflammation has been identified as a key pathogenic mechanism underlying AD, while inflammation has emerged as a possible target for the management and prevention of AD. Several prior studies have demonstrated that medications modulating neuroinflammation might lessen AD symptoms, mostly by controlling neuroinflammatory signaling pathways such as the NF-κB, MAPK, NLRP3, etc, and their respective signaling cascade.

Knowledge, attitude and practice towards physical activity among healthcare students at a public university in Saudi Arabia.

Objective: This research aimed to study the knowledge, attitudes, and practices (KAP) toward physical activity (PA) of healthcare students at King Khalid University in Abha, Saudi Arabia.

Methods: A prospective web-based cross-sectional study was carried out among healthcare students of King Khalid University from March to May 2024. The questionnaire contained questions on sociodemographic details, five questions about knowledge, eight questions about attitudes, and seven practice-related questions.

Factors associated with essential newborn care practices among non-institutional births in urban Bangladesh: evidence from Bangladesh Urban Health Survey 2021.

Background: Non-institutional births remain prevalent in low- and middle-income countries, associated with a majority of adverse maternal and child health outcomes, including maternal and child mortality. Ensuring essential newborn care (ENC) practices for these non-institutional births is crucial for reducing these adverse outcomes. This study aimed to identify the prevalence, and factors associated with the adoption of ENC practices among non-institutional births in urban Bangladesh.

Association between low-calorie sweetener consumption during pregnancy and child health: A systematic review and meta-analysis.

We examined the association between low-calorie sweeteners (LCS) consumption during preconception, pregnancy, and breastfeeding and child health outcomes. A systematic search of electronic databases in PubMed, Embase, Cumulated Index to Nursing and Allied Health Literature, the Cochrane Library, Scopus, Web of Science, PsycINFO, ProQuest Health and Medical, ClinicalTrials.gov, and Google Scholar was conducted up to 21 September 2023.

In Situ Nucleosome Assembly for Single-Molecule Correlative Force and Fluorescence Microscopy.

Nucleosomes constitute the primary unit of eukaryotic chromatin and have been the focus of numerous informative single-molecule investigations regarding their biophysical properties and interactions with chromatin-binding proteins. Nucleosome reconstitution on DNA for these studies typically involves a salt dialysis procedure that provides precise control over the placement and number of nucleosomes formed along a DNA tether. However, this protocol is time-consuming and requires a substantial amount of DNA and histone octamers as inputs.

Comprehensive Analysis of SARS-CoV-2 Dynamics in Bangladesh: Infection Trends and Variants (2020-2023).

The first case of COVID-19 was detected in Bangladesh on 8 March 2020. Since then, the Government of Bangladesh (GoB) has implemented various measures to limit the transmission of COVID-19, including widespread testing facilities across the nation through a laboratory network for COVID-19 molecular testing. This study aimed to analyze the dynamics of SARS-CoV-2 in Bangladesh by conducting COVID-19 testing and genomic surveillance of the virus variants throughout the pandemic.

Assessment of knowledge, attitudes, and practices on vaccine usage among small ruminant farmers in the Northern Region of Bangladesh.

Background And Aim: Small ruminants require vaccines to prevent and manage diseases. Unfortunately, no studies have been conducted in Bangladesh to assess the knowledge, attitudes, and practices (KAP) of small ruminant farmers (SRF) regarding vaccine use against infectious diseases, affecting the success of vaccination campaigns. The present study aims to assess SRF's KAP regarding vaccines, revealing gaps and barriers to efficient vaccination.