Epicardial cell shape and maturation are regulated by Wt1 via transcriptional control of .

The epicardium plays a crucial role in embryonic heart development and adult heart repair; however, the molecular events underlying its maturation remain unknown. , one of the main markers of the embryonic epicardium, is essential for epicardial development and function. Here, we analyse the transcriptomic profile of epicardial-enriched cells at different stages of development and from control and epicardial-specific knockout () mice.

[Detection of LADA-type diabetes in overweight diabetic patients. Is treatment with metformin suitable?].

Objectives: To detect type-1 LADA (latent auto-immune diabetes in adults) in adults with overweight. To describe the metabolic variations in these patients after metformin treatment.

Design: Observational, multi-centre study based on a series of cases.