Innovative suspended ring core fiber for SERS application.

Solid core photonic crystal fibers (SC-PCFs) have garnered attention as probes for surface-enhanced Raman spectroscopy (SERS) due to their potential as optofluidic devices, offering heightened sensitivity and reliability compared to traditional planar/colloidal nanoparticle-based SERS platforms. A smaller core allows for more light interaction but might compromise sensitivity and reliability due to reduced surface area for interaction. Here, we introduce an innovative SC-PCF design aimed at resolving the trade-off between increasing the evanescent field fraction and the core surface area.

Reliable and easy-to-use SERS spectroscopy probe using a tapered opto-fluidic photonic crystal fiber.

Surface enhanced Raman spectroscopy (SERS) is one of the most sensitive biosensing techniques that offers label free detection for a variety of applications. Generally, SERS spectroscopy is performed on nano-functionalized planar substrates with plasmonic structures or colloidal nanoparticles. Recently, photonic crystal fibers (PCFs) have gained great interest for SERS based bio sensing applications due to the immense advantages such as improved sensitivity, flexibility and remote sensing capability that it offers compared to the planar substrates.

Mobile multi-configuration clinical translational Raman system for oral cancer application.

Early diagnosis of oral cancer is critical to improve the survival rate of patients. Raman spectroscopy, a non-invasive spectroscopic technique, has shown potential in identifying early-stage oral cancer biomarkers in the oral cavity environment. However, inherently weak signals necessitate highly sensitive detectors, which restricts widespread usage due to high setup costs.

[Management of fetal growth restriction in France: Survey of teaching hospitals and tertiary referral centers].

Objectives: French Guidelines on Fetal Growth Restriction (FGR) were published in December 2013. It seemed interesting to us to carry out an inventory on the management of FGR in teaching hospitals and tertiary referral centers MATERIAL AND METHODS: We carried out a retrospective survey on the academic year 2020/2021. All teaching hospitals and level III maternity in mainland France were contacted (67).

Optimization and performance analysis of SERS-active suspended core photonic crystal fibers.

Recently, surface enhanced Raman spectroscopy (SERS)-active photonic crystal fiber (PCFs) probes have gained great interest for biosensing applications due to the tremendous advantages it has over the conventional planar substrate based SERS measurements, with improvements on the detection sensitivity and reliability in measurements. So far, two main approaches were employed to get the analyte molecule in the vicinity of nanoparticles (NPs) inside PCFs in order to achieve the SERS effect. In the first case, analyte and NPs are pre-mixed and injected inside the holes of the PCF prior to the measurement.

Development of highly reliable SERS-active photonic crystal fiber probe and its application in the detection of ovarian cancer biomarker in cyst fluid.

Conventionally Surface-enhanced Raman spectroscopy (SERS) is realized by adsorbing analytes onto nano-roughened planar substrate coated with noble metals (silver or gold) or their colloidal nanoparticles (NPs). Nanoscale irregularities in such substrates/NPs could lead to SERS sensors with poor reproducibility and repeatability. Herein, we demonstrate a suspended core photonic crystal fiber (PCF) based SERS sensor with extremely high reproducibility and repeatability in measurement with a relative SD of only 1.

Surface-enhanced Raman scattering-active photonic crystal fiber probe: Towards next generation liquid biopsy sensor with ultra high sensitivity.

The tremendous enhancement factors that surface-enhanced Raman scattering (SERS) possesses coupled with the flexibility of photonic crystal fibers (PCFs) pave the way to a new generation of ultrasensitive biosensors. Thanks to the unique structure of PCFs, which allows direct incorporation of an analyte into the axially aligned air channels, interaction between the analyte and excitation light could be increased many folds leading to flexible, reliable and sensitive probes that can be used in preclinical or clinical biosensing. SERS-active PCF probes provide unique opportunity to develop an opto-fluidic liquid biopsy needle sensor that enables one-step integrated sample collection and testing for disease diagnosis.