The myth of the yo-yo: consistent rate of weight loss with successive dieting by VLCD.

Four subjects in a recent trial of eight weeks dieting with the 405 kcal/day, 42 g protein formula (Cambridge diet extra), had participated 18 months previously in an 8-week trial using the 330 kcal/day Cambridge diet formula. This permitted a quantitative comparison of two similar dieting episodes, but following substantial weight loss and variable weight regain after a successful experience with a very low calorie diet. Within the reasonable bounds of comparison between outpatient dieting experiences, there was no suggestion of impairment in ability to lose weight in subsequent dieting after weight loss on a VLCD.

Phenogenetics of a suppressor and an enhancer gene of the lozenge34k allel of Drosophila melanogaster.

The recessive sex-linked gene, lozenge34k, was initially identified on the basis of its effect on the compound eye of Drosophila melanogaster. However, its pleiotropic effects include modification of the antennae, legs and female reproductive structures as well. Two modifier genes, a third chromosome suppressor, su(lz34k), and a fourth chromosome enhancer, spae(lz), have been previously described and their effects on the various mutant characters of the lozenge34k phenotype were the basis of this study.