Prediction of recurrent disease by cytology and HPV testing after treatment of cervical intraepithelial neoplasia.

Objective: To assess the role of human papillomavirus (HPV) testing and cytology as predictors of residual/recurrent disease after treatment of high-grade cervical intraepithelial lesions.

Methods: One hundred and thirty-eight women with cervical intraepithelial neoplasia (CIN) grade 2/3 lesion on biopsy were included in a prospective follow-up study in Belgium and Nicaragua. All women were treated with loop electrosurgical excision procedure (LEEP) and follow-up visits took place at 6 weeks, 6 months, 1 year and 2 years.

Mistaken identity of widely used esophageal adenocarcinoma cell line TE-7.

Cancer of the esophagus is the seventh leading cause of cancer death worldwide. Esophageal carcinoma cell lines are useful models to study the biological and genetic alterations in these tumors. An important prerequisite of cell line research is the authenticity of the used cell lines because the mistaken identity of a cell line may lead to invalid conclusions.

Human papillomavirus DNA detection in women with primary abnormal cytology of the cervix: prevalence and distribution of HPV genotypes.

Objectives: In this study, we focus on the prevalence and occurrence of different anogenital human papillomavirus (HPV) genotypes in a first abnormal cervical screening test, and correlate HPV genotyping with the cytological diagnosis on thin-layer liquid-based preparations in routine gynaecological screening.

Methods: Out of 780 abnormal smears, 513 tested positive for HPV. All 25 different HPV types were identified by Line Probe Assay.

Bilateral open breast coil and compatible intervention device.

Dynamic contrast-enhanced breast MRI is an extremely sensitive method for breast lesion detection. For MR-only detected lesions it is essential that needle biopsy or localization prior to surgery is carried out under MR guidance. This work describes a bilateral open breast coil and prototype intervention device, which may be used in these situations.

Possible systematic errors in measurements of skin colour using the EEL reflectance spectrophotometer.

Reflectance readings with the EEL Reflectance Spectrophotometer, used in many studies of human skin colour, depend on the spatial orientation of the applicator head of the instrument. Variations of over 15% of the calibration value have been observed. The present paper shows that this orientation dependence is due to the influence of gravity on the glowing spiral of the light bulb.

Complement components in blood serum and suction blister fluid in erythropoietic protoporphyria.

Complement factor's C3c, C4, factor B, C3d and the immunoglobulin IgA were determined in suction blister fluid of patients with erythropoietic protoporphyria and in normal controls. The levels increased when the skin of the patients had been previously irradiated with 'white light', but with Kromayer radiation, and were interpreted as being the result of increased vasopermeability.

A non-invasive microscopic method for measuring epidermal thickness in vivo.

Some improvements are reported of a relatively unknown method for measuring the thickness of the epidermis in vivo. The excursion of a microscope tube is measured when focussing respectively on the summits of the dermal capillary loops and on the epidermal surface. With this method values may be produced with a standard deviation in the order of 10 micron.

Rapid regeneration of the dermal-epidermal junction after partial separation by vacuum: an electron microscopic study.

A process of rapid repair of dermal-epidermal adherence, as found in experiments with interrupted suction, was investigated electron microscopically. Biopsies in different stages of the process of suction blister formation and of the repair process were studied. Results show that suction blister formation occurs by successive detachment of hemidesmosomes from the basement membrane, and that, after partial separation of the epidermis from the dermis, a rapid regeneration of the dermal-epidermal junction takes place.