The diagnostic value of eye movement recordings in patients with Huntington's disease and their offspring.

Eye movements were studied with EOG in a large number of Huntington's disease (HD) patients (N = 48) and their offspring (subjects at risk, N = 97). The following oculomotor paradigms were investigated: horizontal and vertical saccades of different sizes (10-80 degrees), smooth pursuit eye movements, optokinetic and vestibular nystagmus. It was found that 75% of the HD patients had pathologically slow saccades.