Lipid peroxidation and protective enzymes during myocardial infarction.

Fasting blood taken from 34 patients with myocardial infarction, 19 with unstable angina and 40 healthy controls, was analysed for malondialdehyde and erythrocyte detoxification enzymes, superoxide dismutase and glutathione peroxidase. Malondialdehyde concentration was raised in the patients with myocardial infarction during the initial 48 h after an attack, and correlated with the severity of the attack. 12 days after the infarct, malondialdehyde concentrations were lower but still raised.

The evolution of oxidative stress indicators in the course of myocardial ischemia.

Two studies were carried out in patients suffering from Unstable Angina (UA) and Myocardial Infarction (MI). The first study investigated the variations of the Malondialdehyde (MDA) rate at 1st, 5th, 12th day of treatment in 27 patients (15 UA and 12 MI), compared to 15 controls. This rate varied in a different way, with a first peak and a rapid decrease in UA, where it regularly decreases in MI.

Study of fatty acids in atheroma induced in rabbits by an atherogenic diet with or without silicon i.v. treatment.

Fifty-two rabbits were submitted for two months to an atherogenic diet with or without addition of silicon in the form of an I.V. silicon organic compound and compared to a control group of 21 rabbits.

[HDL2 and HDL3 cholesterol in men and women in different forms of hyperlipidemia without arterial involvement].

The investigation was carried out in one hand on 54 hyperlipidemic men without arterial injury compared to 54 normolipidemic men, on the other hand on 50 hyperlipidemic women compared to 50 normolipidemic women. The hyperlipidemic subjects were separated in IIa, IIb and IV groups, according to WHO classification. Lipoprotein's separation was carried out by sequently ultracentrifugation and HDL2-HDL3 were isolated at a solvant density of 1.

[Membrane lipid peroxidation in coronary insufficiency].

Malondialdehyde (MDA) as lipid peroxidation marker was studied in 27 patients with acute coronary insufficiency. Significantly elevated plasma levels as compared with controls were found in patients with myocardial necrosis and with preinfarction syndrome. No correlation was found between MDA and creatine phosphokinase, and a significant MDA decrease was observed at day 12: plasma MDA reached normal levels in the myocardial necrosis group.

[Fatty acid and lipid peroxidation in human atherosclerosis].

Plasma fatty acids and lipid peroxidation were studied in human atherosclerosis. Analysis of fatty acids in 16 controls and 32 hyperlipidemic patients showed, in the latter, a decrease in saturated fatty acids, especially palmitic and stearic acids, and an increase in unsaturated fatty acids, especially arachidonic acid. Compared to hyperlipidemic patients without arterial injury, patients with arterial injury exhibit a significant increase in malonaldehyde (MDA).