Short-term effects of dapagliflozin on biomarkers of bone and mineral metabolism in patients with diabetic kidney disease: A prospective observational study.

Background: There is still a lack of information regarding the impact of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on bone and mineral metabolism in patients with diabetes and chronic kidney disease (CKD). Therefore, we aimed to investigate the effects of SGLT2i in a cohort of patients suffering from diabetic kidney disease (DKD).

Methods: In this prospective observational study, patients with type 2 diabetes and biopsy-proven diabetic nephropathy or presumptive DKD with eGFR levels ≥20 ml/min/1.

Machine Learning-Aided Inverse Design and Discovery of Novel Polymeric Materials for Membrane Separation.

Polymeric membranes have been widely used for liquid and gas separation in various industrial applications over the past few decades because of their exceptional versatility and high tunability. Traditional trial-and-error methods for material synthesis are inadequate to meet the growing demands for high-performance membranes. Machine learning (ML) has demonstrated huge potential to accelerate design and discovery of membrane materials.

Synergistic enhancement of hydrophobic dental adhesives: autonomous strengthening, polymerization kinetics, and hydrolytic resistance.

The leading cause of composite restoration failure is recurrent marginal decay. The margin between the composite and tooth is initially sealed by a low-viscosity adhesive, but chemical, physical, and mechanical stresses work synergistically and simultaneously to degrade the adhesive, destroying the interfacial seal and providing an ideal environment for bacteria to proliferate. Our group has been developing self-strengthening adhesives with improved chemical and mechanical characteristics.

Pulmonary rehabilitation in connective tissue disease-associated interstitial lung disease: A systematic review.

Background And Aim:  Interstitial lung disease (ILD) is the major contributor to mortality in between chronic lung diseases. ILD originates from voluminous pathophysiological factors. One of the reasons is connective tissue diseases (CTD).

Examining the Burnout of Audiologists in Türkiye: Relationships With Quality of Work Life and Psychological Well-Being.

Purpose: Although burnout among audiologists has been studied in various countries, there is no research yet that examines this issue in Türkiye, where working conditions and sociodemographic factors may differ from those in other countries. Considering the unique working conditions and sociodemographic factors, this study aimed to investigate the burnout levels of Turkish audiologists. Additionally, this study will explore the impact of various sociodemographic variables on burnout, work-related quality of life, and depression to gain a deeper understanding of the specific challenges faced by audiologists in Türkiye.

Evaluation of genetic diversity in some hybrid individuals of honeyberry (Lonicera caerulea L.) based on fruit characteristics, leaf morphology, vitamin C, antioxidant activity, and biochemical and nutritional contents.

Background: Genetic diversity is a prerequisite for breeding programs, and one of the main goals here is to obtain quality products. Therefore, this study aims to evaluate the genetic diversity in some hybrid individuals of honeyberry (Lonicera caerulea L.) based on fruit characteristics, leaf morphology, vitamin C, antioxidant activity, biochemical, and nutritional content.

Accelerated Phase Contrast MRI with Use of Resolution Enhancement Generative Adversarial Neural Network.

Background: Cardiovascular magnetic resonance (CMR) phase-contrast is used to quantify blood flow. We sought to develop a complex-difference reconstruction for inline super-resolution of phase-contrast (CRISPFlow) to accelerate phase-contrast imaging.

Methods: CRISPFlow was built on the super-resolution generative adversarial network.

Late Gadolinium Enhancement CMR with Generative AI.

Background: Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging enables imaging of scar/fibrosis and is a cornerstone of most CMR imaging protocols. CMR imaging can benefit from image acceleration; however, image acceleration in LGE remains challenging due to its limited signal-to-noise ratio. In this study, we sought to evaluate a rapid 2D LGE imaging protocol using a generative artificial intelligence (AI) algorithm with inline reconstruction.

Multivariate analysis of morphological variation, biochemical content, antioxidant activity, and molecular characteristics of autochthonous Berberis crataegina DC. genotypes in Central Türkiye.

Background: One of the wild fruit species with a natural distribution in Türkiye, and historically used for medicinal purposes due to its rich composition, is Berberis crataegina DC. Various parts of the plant, including its roots, bark, leaves, flowers, and fruits, have been utilized in traditional medicine, while its fruits are also consumed in various forms as food. This study aimed to characterize the morphological, biochemical, and molecular traits of B.

A Novel Information Complexity Approach to Score Receiver Operating Characteristic (ROC) Curve Modeling.

Performance metrics are measures of success or performance that can be used to evaluate how well a model makes accurate predictions or classifications. However, there is no single measure since each performance metric emphasizes a different classification aspect. Model selection procedures based on information criteria offer a quantitative measure that balances model complexity with goodness of fit, providing a better alternative to classical approaches.

Relationship between post traumatic stress disorder and hand dimensions and hand grip strength in children aged 8-12 exposed to earthquakes.

Earthquakes cause severe destruction in the region where they occur. Children and adolescents are the group most affected group by earthquakes, and Post-Traumatic Stress Disorder is most common in this group. The age-related increase in Grip Strength varies between childhood and early adolescence.

Extremely low frequency pulsed magnetic field inhibits myocardial damage and apoptosis in rats with CLP-induced sepsis: A histopathological and immunohistochemical evaluation.

We aimed to investigate whether pulsed magnetic fields (PMFs) (1 mT) may have preventive effects on myocardial damage and apoptosis in rats with sepsis. Twenty-eight adult Wistar albino rats were evenly distributed among four experimental groups, each consisting of seven rats: SH, LF-PMF, HF-PMF, and CLP. Sepsis induction was carried out via the cecal ligation and puncture (CLP) method, while rats in the LF-PMF and HF-PMF groups were exposed to 7.

A Novel Heterozygous NFKB2 Variant in a Multiplex Family with Common Variable Immune Deficiency and Autoantibodies Against Type I IFNs.

We studied a family with three male individuals across two generations affected by common variable immune deficiency (CVID). We identified a novel missense heterozygous variant (c.2602T>A:p.

Validity of a virtual reality-based straight coloanal anastomosis simulator.

Purpose: Current training methods for surgical trainees are inadequate because they are costly, low-fidelity, or have a low skill ceiling. This work aims to expand available virtual reality training options by developing a VR trainer for straight coloanal anastomosis (SCA), one of the Colorectal Objective Structured Assessment of Technical Skills (COSATS) tasks.

Methods: We developed a VR-based SCA simulator to evaluate trainees based on their performance.

Evaluation of the fabrication trueness and internal fit of additively manufactured two-piece zirconia abutments with different build orientations compared to subtractively manufactured abutments.

Objective: To evaluate the effect of build orientation on the fabrication trueness and fit of additively manufactured 2-piece zirconia abutments when compared with those manufactured subtractively in 3 mol% and 4 mol% yttria-stabilized zirconia (3Y-TZP and 4Y-TZP).

Methods: A titanium-base (Ti-base) abutment was digitized with a scan body and an industrial scanner to design a 2-piece zirconia abutment with a 50 µm cement gap. This design was used to manufacture zirconia abutments additively in different orientations (0-degree, AM-0; 15-degree, AM-15; 30-degree, AM-30; 45-degree, AM-45; 180-degree, AM-180) and subtractively from 3Y-TZP and 4Y-TZP (SM-3 and SM-4) (n=5).

Pre-Stroke Frailty Negatively Affects Leptomeningeal Collateral Flow in Proximal Middle Cerebral Artery Occlusion.

Introduction: The adequacy of blood flow from the leptomeningeal collaterals is considered one of the most important factors determining the rate of infarct progression and response to acute stroke treatments in the setting of large vessel occlusions. Several patient-related variables, including age, vascular risk factors, and laboratory parameters, have been proposed to explain the interindividual variability of collateral flow among stroke patients. This study aimed to assess how pre-stroke frailty, an aging-related syndrome characterized by a loss in the physiologic reserve of numerous body functions, affected the degree of leptomeningeal collateral flow in the setting of acute ischemic stroke.

Management of Children with Megafoot Secondary to Proteus Syndrome: A Report of Three Cases with Long-Term Follow-Up.

Background: Proteus syndrome is a rare disorder characterized by overgrowth of limbs and organs and neurocutaneous findings.

Methods: We examined three Proteus syndrome cases with unilateral foot enlargement, megafoot. The patients had ambulatory and cosmetic difficulties.

Bone mineral density and TAVR outcome: A comparative analysis between patients with enhanced and non-enhanced TAVR CT scans.

Background: Preprocedural evaluation, including frailty estimation, is crucial in managing patients undergoing Transcatheter Aortic Valve Replacement (TAVR). This involves mandatory computed tomography (CT) scans for assessing body composition parameters. The impact of low bone mineral density (BMD) on TAVR outcomes remains unclear, especially when measured using both non-enhanced and contrast-enhanced CT scans.

Impact of high-fructose diet and metformin on histomorphological and molecular parameters of reproductive organs and vaginal microbiota of female rat.

There are limited data on the effects of a high-fructose diet on the female reproductive system. Although metformin has some functional effects on female fertility, its reproductive outcome on high fructose diet-induced metabolic syndrome is unclear. The aim of the present study is to evaluate the impact of a high fructose diet on histomorphological and molecular parameters of the reproductive organs and vaginal microbiota as well as the treatment potential of metformin.

Histopathological and radiological evaluation of the efficacy of hydroxyapatite-boric acid and hydroxyapatite-magnesium coated Kirschner wires on fracture healing in femoral diaphyseal fractures: an experimental study.

Background: Biomaterials used in fracture healing hold a significant place in orthopedics. This study aimed to develop biomaterials coated with hydroxyapatite (HA), boric acid (BA), and magnesium (Mg) and investigate their effects on fracture healing.

Methods: Sixty female Wistar Albino rats were included in the study.

Visual grading of valvular regurgitation is inferior to measurement - results from the VIAVA-study (VIsual Assessment of VAlvular Regurgitation).

While the visual estimation of systolic left ventricular function by experienced examiners closely aligns with quantitative methodologies, the accuracy of visual estimation in determining the severity of valvular regurgitation using colour flow Doppler assessment of native heart valves remains largely unexplored. This study analysed the ability of 262 physicians to visually estimate the severity of 12 native valve regurgitations by grading colour Doppler transthoracic echocardiography loops in an online questionnaire. The assessments of the participants were compared to standardized quantitative evaluations conducted by certified echocardiography experts.