T2 Magnetic Resonance Assay-Based Direct Detection of Three Lyme Disease-Related Borrelia Species in Whole-Blood Samples.

In early Lyme disease (LD), serologic testing is insensitive and seroreactivity may reflect active or past infection. In this study, we evaluated a novel assay for the direct detection of three species of spirochetes in whole blood. The T2 magnetic resonance (T2MR) assay platform was used to amplify DNA released from intact spirochetes and to detect amplicon.